ArticleScientific reports2018
The Virtual-Environment-Foraging Task enables rapid training and single-trial metrics of attention in head-fixed mice.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Sharing the spotlight: Uncovering common attentional dynamics across species.PLoS computational biology · 2026Article
- Inferring internal states across mice and monkeys using facial features.Nature communications · 2025Article
- Moculus: an immersive virtual reality system for mice incorporating stereo vision.Nature methods · 2025Article
- DomeVR: Immersive virtual reality for primates and rodents.PloS one · 2025Article
- Regularizing hyperparameters of interacting neural signals in the mouse cortex reflect states of arousal.PLoS computational biology · 2024Article
- What does the mean mean? A simple test for neuroscience.PLoS computational biology · 2024Article
- Advancing preclinical chronic stress models to promote therapeutic discovery for human stress disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- A mild impairment in reversal learning in a bowl-digging substrate deterministic task but not other cognitive tests in the Dlg2+/- rat model of genetic risk for psychiatric disorder.Genes, brain, and behavior · 2023Article
- Distributed context-dependent choice information in mouse posterior cortex.Nature communications · 2023Article
- Refinements to rodent head fixation and fluid/food control for neuroscience.Journal of neuroscience methods · 2022Review
- Reconstruction of ovine axonal cytoarchitecture enables more accurate models of brain biomechanics.Communications biology · 2022Article
- Shared and specialized coding across posterior cortical areas for dynamic navigation decisions.Neuron · 2022Article
- The Virtual-Environment-Foraging Task enables rapid training and single-trial metrics of rule acquisition and reversal in head-fixed mice.Scientific reports · 2019Article
- A Visual Two-Choice Rule-Switch Task for Head-Fixed Mice.Frontiers in behavioral neuroscience · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Attention - the flexible allocation of processing resources based on behavioural demands - is essential to survival. Mouse research offers unique tools to dissect the underlying pathways, but is hampered by the difficulty of accurately measuring attention in mice. Current attention tasks for mice face several limitations: Binary (hit/miss), temporally imprecise metrics, behavioural confounds and overtraining. Thus, despite the increasing scope of neuronal population measurements, insights are limited without equally precise behavioural measures. Here we present a virtual-environment task for head-fixed mice based on 'foraging-like' navigation. The task requires animals to discriminate gratings at orientation differences from 90° to 5°, and can be learned in only 3-5 sessions (<550 trials). It yields single-trial, non-binary metrics of response speed and accuracy, which generate secondary metrics of choice certainty, visual acuity, and most importantly, of sustained and cued attention - two attentional components studied extensively in humans. This allows us to examine single-trial dynamics of attention in mice, independently of confounds like rule learning. With this approach, we show that C57/BL6 mice have better visual acuity than previously measured, that they rhythmically alternate between states of high and low alertness, and that they can be prompted to adopt different performance strategies using minute changes in reward contingencies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.