SynthesisNature communications2018
Systematic review of indoor residual spray efficacy and effectiveness against Plasmodium falciparum in Africa.
Synthesis in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 83 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Rwanda
Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Mozambique
Who cites it
83 citing papers in PubMed, 5 syntheses or guidelines pooled it, 146 citations in OpenAlex.
- Knockdown resistance (kdr) associated organochlorine resistance in mosquito-borne diseases (Culex quinquefasciatus): Systematic study of reviews and meta-analysis.PLoS neglected tropical diseases · 2024Pooled it
- Inferring the epidemiological benefit of indoor vector control interventions against malaria from mosquito data.Nature communications · 2022Pooled it
- Indoor residual spraying for preventing malaria in communities using insecticide-treated nets.The Cochrane database of systematic reviews · 2022Pooled it
- Pooled it
- Mosquito feeding behavior and how it influences residual malaria transmission across Africa.Proceedings of the National Academy of Sciences of the United States of America · 2019Pooled it
- Trial
- Effectiveness and cost-effectiveness of reactive, targeted indoor residual spraying for malaria control in low-transmission settings: a cluster-randomised, non-inferiority trial in South Africa.Lancet (London, England) · 2021Trial
- Determinants of malaria prevalence among children under 5 years of age in 17 sub-Saharan African countries: insights from Malaria Indicator Surveys.Global health action · 2026Article
- Mosquito-based malaria control through genetic, microbial and immunological innovations.Nature reviews. Microbiology · 2026Review
- Article
- Local implementation of scalable malaria molecular surveillance in a low-resource setting: a North-South collaborative model.Malaria journal · 2026Article
- Mechanisms of carbamate resistance in the malaria vector:Parasite epidemiology and control · 2026Review
- Insecticidal efficacy of residual spraying with deltamethrin-clothianidin (FludoraParasites & vectors · 2026Article
- Susceptibility ofCurrent research in parasitology & vector-borne diseases · 2026Article
- Malaria incidence rose following the introduction of neonicotinoid-based IRS in selected districts in northern Ghana: An observational analysis.PLOS global public health · 2026Article
- Predictive chemoproteomics and functional validation reveal Coeae6g-mediated insecticide cross-resistance in the malaria vector Anopheles gambiae.Nature communications · 2025Article
- A costing analysis of an intermittent biolarviciding intervention with limited epidemiological effect in Tanga Region, Tanzania.Malaria journal · 2025Article
- Reconsidering indoor residual spraying coverage targets: A retrospective analysis of high-resolution programmatic malaria control data.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Exploring the epidemiological impact of attractive targeted sugar bait against malaria in combination with standard malaria control.Current research in parasitology & vector-borne diseases · 2025Article
- Nowcasting Vector Mosquito Abundance and Determining Its Association With Malaria Epidemics in South Korea.Transboundary and emerging diseases · 2025Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 11 institutions in 7 countries.
Funding
Abstract
Indoor residual spraying (IRS) is an important part of malaria control. There is a growing list of insecticide classes; pyrethroids remain the principal insecticide used in bednets but recently, novel non-pyrethroid IRS products, with contrasting impacts, have been introduced. There is an urgent need to better assess product efficacy to help decision makers choose effective and relevant tools for mosquito control. Here we use experimental hut trial data to characterise the entomological efficacy of widely-used, novel IRS insecticides. We quantify their impact against pyrethroid-resistant mosquitoes and use a Plasmodium falciparum transmission model to predict the public health impact of different IRS insecticides. We report that long-lasting IRS formulations substantially reduce malaria, though their benefit over cheaper, shorter-lived formulations depends on local factors including bednet use, seasonality, endemicity and pyrethroid resistance status of local mosquito populations. We provide a framework to help decision makers evaluate IRS product effectiveness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.