ArticleNature ecology & evolution2019
Multiple episodes of interbreeding between Neanderthal and modern humans.
Article in Nature ecology & evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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74 citing papers in PubMed.
- Faster inference of complex demographic models from large allele frequency spectra.Bioinformatics (Oxford, England) · 2026Article
- A global map for introgressed structural variation and selection in humans.Science (New York, N.Y.) · 2026Article
- Chromosome-level genome assembly of Trichiurus japonicus resolves species boundaries and evolutionary history of cutlassfishes in Northwest Pacific.BMC genomics · 2026Article
- AI solutions for evolutionary genomics of nonmodel species.Evolution letters · 2026Review
- Genomic Signatures of Speciation in Butterflies.Systematic biology · 2026Article
- Recent advances in methods to characterize archaic introgression in modern humans.Genome research · 2026Review
- Archaic adaptive introgression in modern human reproductive genes.Communications biology · 2025Article
- TheScience (New York, N.Y.) · 2025Article
- Parallels and discrepancies between non-native species introductions and human migration.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Why Are Some Snakes More Terrifying and What Is Behind the Fear?Animals : an open access journal from MDPI · 2025Article
- Archaic introgression and the distribution of shared variation under stabilizing selection.PLoS genetics · 2025Article
- Human dispersal into East Eurasia: ancient genome insights and the need for research on physiological adaptations.Journal of physiological anthropology · 2025Review
- Dentition of the Mugharet El'Aliya Fossil Human Maxilla, Morocco.American journal of biological anthropology · 2025Article
- Adaptive introgression in modern human circadian rhythm genes.Npj biological timing and sleep · 2025Article
- Neanderthal ancestry through time: Insights from genomes of ancient and present-day humans.Science (New York, N.Y.) · 2024Article
- Personhood Begins at Birth: The Rational Foundation for Abortion Policy in a Secular State.Journal of bioethical inquiry · 2024Article
- Computational Genomics and Its Applications to Anthropological Questions.American journal of biological anthropology · 2024Review
- Initial Upper Palaeolithic lithic industry at Cueva Millán in the hinterlands of Iberia.Scientific reports · 2024Article
- Recurrent gene flow between Neanderthals and modern humans over the past 200,000 years.Science (New York, N.Y.) · 2024Article
- Neandertal ancestry through time: Insights from genomes of ancient and present-day humans.bioRxiv : the preprint server for biology · 2024Article
14 more citing papers are in PubMed but not listed here.
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Abstract
Neanderthals and anatomically modern humans overlapped geographically for a period of over 30,000 years following human migration out of Africa. During this period, Neanderthals and humans interbred, as evidenced by Neanderthal portions of the genome carried by non-African individuals today. A key observation is that the proportion of Neanderthal ancestry is ~12-20% higher in East Asian individuals relative to European individuals. Here, we explore various demographic models that could explain this observation. These include distinguishing between a single admixture event and multiple Neanderthal contributions to either population, and the hypothesis that reduced Neanderthal ancestry in modern Europeans resulted from more recent admixture with a ghost population that lacked a Neanderthal ancestry component (the 'dilution' hypothesis). To summarize the asymmetric pattern of Neanderthal allele frequencies, we compiled the joint fragment frequency spectrum of European and East Asian Neanderthal fragments and compared it with both analytical theory and data simulated under various models of admixture. Using maximum-likelihood and machine learning, we found that a simple model of a single admixture did not fit the empirical data, and instead favour a model of multiple episodes of gene flow into both European and East Asian populations. These findings indicate a longer-term, more complex interaction between humans and Neanderthals than was previously appreciated.
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