ArticleGenes & development2018
Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in
Open access · diamondAbstract read
In one paragraph
Article in Genes & development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Prefoldin function links meiotic chromosome segregation with cellular remodeling and reveals tubulin sensitivity of the meiotic spindle.Science advances · 2026Article
- Prefoldin function links meiotic chromosome segregation with cellular remodeling and reveals tubulin sensitivity of the meiotic spindle.bioRxiv : the preprint server for biology · 2026Article
- HSF-1 Regulates Autophagy to Govern Motor Function and Facilitate Toxic Protein Clearance in a C. elegans Model of Amyotrophic Lateral Sclerosis.Neuroscience bulletin · 2026Article
- Transcriptomic profiles of susceptibility and resilience to stress in the amygdala and hippocampus of male rats.Neurobiology of stress · 2025Article
- Activation of Nuclear Receptor CAR: A Pathway to Delay Aging through Enhanced Capacity for Xenobiotic Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Combinatorial transcriptomic and genetic dissection of insulin/IGF-1 signaling-regulated longevity in Caenorhabditis elegans.Aging cell · 2024Article
- Prefoldin Subunits and Its Associate Partners: Conservations and Specificities in Plants.Plants (Basel, Switzerland) · 2024Review
- Magnolol extends lifespan and improves age-related neurodegeneration in Caenorhabditis elegans via increase of stress resistance.Scientific reports · 2024Article
- Recent Progress in Regulation of Aging by Insulin/IGF-1 Signaling inMolecules and cells · 2022Review
- Hijacking Cellular Stress Responses to Promote Lifespan.Frontiers in aging · 2022Review
- HSF-1: Guardian of the Proteome Through Integration of Longevity Signals to the Proteostatic Network.Frontiers in aging · 2022Review
- MON-2, a Golgi protein, mediates autophagy-dependent longevity inScience advances · 2021Article
- Review
- A genetic approach reveals different modes of action of prefoldins.Plant physiology · 2021Article
- A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling.Nature communications · 2021Article
- Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP-mediated feedforward loop.The Journal of cell biology · 2021Article
- Identification and functional analyses of host factors interacting with the 17-kDa protein of Barley yellow dwarf virus-GAV.Scientific reports · 2021Article
- Prefoldin Function in Cellular Protein Homeostasis and Human Diseases.Frontiers in cell and developmental biology · 2021Review
- Healthspan Enhancement by Olive Polyphenols inInternational journal of molecular sciences · 2020Article
- Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males.iScience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 5 institutions in 3 countries.
Heehwa G SonDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea.
Keunhee SeoDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea.
Mihwa SeoDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea.
Sangsoon ParkDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea.
Seokjin HamDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea.
Seon Woo A AnDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea.
Eun-Seok ChoiDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea.
Yujin LeeDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea.
Haeshim BaekDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea.
Eunju KimDepartment of Internal Medicine, Division of Geriatric and Palliative Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
Youngjae RyuResearch Division, Korea Brain Research Institute, Daegu 41068, South Korea.
Chang Man HaResearch Division, Korea Brain Research Institute, Daegu 41068, South Korea.
Ao-Lin HsuDepartment of Internal Medicine, Division of Geriatric and Palliative Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
Tae-Young RohDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea.
Sung Key JangDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea.
Seung-Jae V LeeDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea.
Pohang University of Science and Technology · KRKorea Brain Research Institute · KRChina Medical University · TWDaegu Gyeongbuk Institute of Science and Technology · KRUniversity of Michigan–Ann Arbor · US
Funding
Regulation of Heat Shock Transcription Factor in Long-lived AnimalsR01AG028516 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HSU, AO-LIN ALLEN · 2008 to 2017
$2.8MNIA NIH HHS R01 AG028516
Abstract
Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In
Indexed as
AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsForkhead Transcription FactorsInsulinInsulin-Like Growth Factor IIntestinesLongevityMolecular ChaperonesProtein BindingSignal TransductionSubcutaneous TissueTranscriptional ActivationTranscription FactorsCaenorhabditis elegans Proteinsdaf-16 protein, C elegansForkhead Transcription Factorsheat shock factor-1, C elegansInsulinInsulin-Like Growth Factor IMolecular ChaperonesTranscription FactorsagingC. elegansDAF-16/FOXOHSF-1/HSF1PFD-6/PFDN6
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.