Evidence map›Paper›PMID 30478238›Full record

ArticlePediatrics2018

Being Overweight or Obese and the Development of Asthma.

Jason E Lang, H Timothy Bunnell, Md Jobayer Hossain, Tim Wysocki, John J Lima, Terri H Finkel, Leonard Bacharier, Amanda Dempsey, Lisa Sarzynski, Matthew Test and 1 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 4 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 4 syntheses or guidelines pooled it, 159 citations in OpenAlex.

  1. Comparative response to pharmacological management of asthma in overweight/obese childrenEuropean respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Obesity-Related Asthma: Structure and Inflammation.Current allergy and asthma reports · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. T cell dysregulation and remodeling in pediatric obesity and weight loss.bioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Associations between body weight, asthma burden, and type 2 inflammation among under-resourced children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026
    Article
  12. Review
  13. Observational
  14. Review
  15. National Economic Burden of Pediatric Asthma Hospitalizations.Annals of the American Thoracic Society · 2025
    Article
  16. Review
  17. Article
  18. Barriers to Healthy Eating and Influences on the Dietary Patterns and Eating Behaviours of 18-36-Month-Old Children in Ireland.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025
    Article
  19. Article
  20. Article

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 1 country.

Jason E LangNemours Children's Hospital, Nemours Children's Health System, Orlando, Florida; jason.lang@duke.org.
H Timothy BunnellDepartment of Biomedical Research, Nemours Alfred I. DuPont Hospital for Children, Wilmington, Delaware.
Md Jobayer HossainDepartment of Biomedical Research, Nemours Alfred I. DuPont Hospital for Children, Wilmington, Delaware.
Tim WysockiCenters for Health Care Delivery Science and.
John J LimaPharmacogenomics and Translational Research, Nemours Children's Health System, Jacksonville, Florida.
Terri H FinkelNemours Children's Hospital, Nemours Children's Health System, Orlando, Florida.
Leonard BacharierDepartment of Pediatrics, Washington University, St Louis, Missouri.
Amanda DempseyDepartment of Pediatrics, School of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, Colorado.
Lisa SarzynskiSection of Pulmonary Medicine, Nationwide Children's Hospital and Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, Ohio.
Matthew TestDepartment of Pediatrics, Seattle Children's Hospital, Seattle, Washington; and.
Christopher B ForrestDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
DuPont (United States) · USNemours Children's Health System · USChildren's Hospital of Philadelphia · USDuke University · USNationwide Children's Hospital · USSeattle Children's Hospital · USUniversity of Colorado Anschutz Medical Campus · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAdult obesity is linked to asthma cases and is estimated to lead to 250 000 new cases yearly. Similar incidence and attributable risk (AR) estimates have not been developed for children. We sought to describe the relationship between overweight and obesity and incident asthma in childhood and quantify AR statistics in the United States for overweight and obesity on pediatric asthma.

methodsThe PEDSnet clinical data research network was used to conduct a retrospective cohort study (January 2009-December 2015) to compare asthma incidence among overweight and/or obese versus healthy weight 2- to 17-year-old children. Asthma incidence was defined as ≥2 encounters with a diagnosis of asthma and ≥1 asthma controller prescription. Stricter diagnostic criteria involved confirmation by spirometry. We used multivariable Poisson regression analyses to estimate incident asthma rates and risk ratios and accepted formulas for ARs.

resultsData from 507 496 children and 19 581 972 encounters were included. The mean participant observation period was 4 years. The adjusted risk for incident asthma was increased among children who were overweight (relative risk [RR]: 1.17; 95% confidence interval [CI]: 1.10-1.25) and obese (RR: 1.26; 95% CI: 1.18-1.34). The adjusted risk for spirometry-confirmed asthma was increased among children with obesity (RR: 1.29; 95% CI: 1.16-1.42). An estimated 23% to 27% of new asthma cases in children with obesity is directly attributable to obesity. In the absence of overweight and obesity, 10% of all cases of asthma would be avoided.

conclusionsObesity is a major preventable risk factor for pediatric asthma.

Indexed as

Risk AssessmentAdolescentAsthmaBody Mass IndexChildChild, PreschoolFemaleFollow-Up StudiesHumansIncidenceMaleObesityOverweightRetrospective StudiesRisk FactorsUnited States

Identifiers

PMID30478238
OpenAlexW2902707066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.