Evidence map›Paper›PMID 30478164›Full record

ArticleAntimicrobial agents and chemotherapy2019

Leishmanicidal Activity of Isoselenocyanate Derivatives.

Celia Fernández-Rubio, Esther Larrea, José Peña Guerrero, Eduardo Sesma Herrero, Iñigo Gamboa, Carlos Berrio, Daniel Plano, Shantu Amin, Arun K Sharma, Paul A Nguewa

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Characterization ofAnimals : an open access journal from MDPI · 2023
    Article
  4. Article
  5. Article
  6. [Leishmaniasis in Navarra, Spain (1976-2018): an update].Anales del sistema sanitario de Navarra · 2022
    Review
  7. Review
  8. InInternational journal of molecular sciences · 2021
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. LmjF.22.0810 fromBiomedicines · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Celia Fernández-Rubio *Universidad de Navarra, Instituto de Salud Tropical (ISTUN), Pamplona, Spain.
Esther Larrea *Universidad de Navarra, Instituto de Salud Tropical (ISTUN), Pamplona, Spain.
José Peña Guerrero *Universidad de Navarra, Instituto de Salud Tropical (ISTUN), Pamplona, Spain.
Eduardo Sesma HerreroUniversidad de Navarra, Instituto de Salud Tropical (ISTUN), Pamplona, Spain.
Iñigo GamboaUniversidad de Navarra, Instituto de Salud Tropical (ISTUN), Pamplona, Spain.
Carlos BerrioUniversidad de Navarra, Instituto de Salud Tropical (ISTUN), Pamplona, Spain.
Daniel PlanoUniversidad de Navarra, Instituto de Salud Tropical (ISTUN), Pamplona, Spain.
Shantu AminDepartment of Pharmacology, Penn State Cancer Institute, CH72, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Arun K SharmaDepartment of Pharmacology, Penn State Cancer Institute, CH72, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Paul A NguewaUniversidad de Navarra, Instituto de Salud Tropical (ISTUN), Pamplona, Spain panguewa@unav.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional chemotherapy against leishmaniasis includes agents exhibiting considerable toxicity. In addition, reports of drug resistance are not uncommon. Thus, safe and effective therapies are urgently needed. Isoselenocyanate compounds have recently been identified with potential antitumor activity. It is well known that some antitumor agents demonstrate effects against

Indexed as

Amphotericin BAnimalsAntiprotozoal AgentsCell Cycle CheckpointsLeishmania majorLeishmania mexicanaLeishmaniasis, CutaneousMacrophages, PeritonealMiceMice, Inbred BALB COrganoselenium CompoundsSulfur CompoundsAmphotericin BAntiprotozoal AgentsisoselenocyanateOrganoselenium CompoundsSulfur CompoundsisoselenocyanateLeishmaniaMCM4PCNAtopoisomerases

Identifiers

PMID30478164
PMCPMC6355615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.