Evidence map›Paper›PMID 30478117›Full record

ArticleBMJ open2018

Associations of lifestyle and vascular risk factors with Alzheimer's brain biomarker changes during middle age: a 3-year longitudinal study in the broader New York City area.

Michelle J Walters, Joanna Sterling, Crystal Quinn, Christine Ganzer, Ricardo S Osorio, Randolph D Andrews, Dawn C Matthews, Shankar Vallabhajosula, Mony J de Leon, Richard S Isaacson and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  7. Physical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michelle J WaltersDepartment of Neurology, Weill Cornell Medical College, New York, USA.ORCID 0000-0003-2908-6779
Joanna SterlingDepartment of Psychology, Woodrow Wilson School of Public and International Affairs, Princeton University, Princeton, New Jersey, USA.
Crystal QuinnDepartment of Psychiatry, New York University School of Medicine, New York, USA.
Christine GanzerHunter-Bellevue School of Nursing, Hunter College, New York, USA.
Ricardo S OsorioDepartment of Psychiatry, New York University School of Medicine, New York, USA.
Randolph D AndrewsADM Diagnostics, Northbrook, Illinois, USA.
Dawn C MatthewsADM Diagnostics, Northbrook, Illinois, USA.
Shankar VallabhajosulaDepartment of Radiology, Weill Cornell Medical College, New York, USA.
Mony J de LeonDepartment of Psychiatry, New York University School of Medicine, New York, USA.
Richard S IsaacsonDepartment of Neurology, Weill Cornell Medical College, New York, USA.
Lisa MosconiDepartment of Neurology, Weill Cornell Medical College, New York, USA.

Funding

Timing of Menopausal Hormone Therapy across Perimenopause to Menopause Transition: Neuroimmune System in BrainP01AG026572 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Schantel Williams · 2006 to 2026
$53.7M
PSYCHOSOCIAL COREP30AG008051 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHAO, YONGZHAO · 1990 to 2019
$36.1M
Sex Differences in the Molecular Determinants of Alzheimer's Disease Risk: Prodromal EndophenotypeR01AG057931 · NIA · UNIVERSITY OF ARIZONA · PI BRINTON, ROBERTA EILEEN, CHANG, RUI · 2018 to 2022
$6.0M
Maternal history of Alzheimer's predisposes children to amyloid beta-related hypoR01AG035137 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MOSCONI, LISA · 2010 to 2014
$2.7M
NIA NIH HHS P01 AG026572NIA NIH HHS P30 AG008051NIA NIH HHS R01 AG035137NIA NIH HHS R01 AG057931
6 · The paper itself

Abstract

objectiveTo investigate the associations between lifestyle and vascular risk factors and changes in Alzheimer's disease (AD) biomarkers (beta-amyloid load via

designProspective, longitudinal.

settingThe study was conducted at New York University Langone/Weill Cornell Medical Centres in New York City.

participantsSeventy cognitively normal participants from multiple community sources, aged 30-60 years with lifestyle measures (diet, intellectual activity and physical activity), vascular risk measures and two imaging biomarkers visits over at least 2 years, were included in the study. OUTCOME MEASURES: We examined MRI-based cortical thickness, fluoro-deoxy-glucose (FDG) glucose metabolism and PiB beta-amyloid in AD-vulnerable regions. A global cognitive z-score served as our summary cognition measure. We used regression change models to investigate the associations of clinical, lifestyle and vascular risk measures with changes in AD biomarkers and global cognition.

resultsDiet influenced changes in glucose metabolism, but not amyloid or cortical thickness changes. With and without accounting for demographic measures, vascular risk and baseline FDG measures, lower adherence to a Mediterranean-style diet was associated with faster rates of FDG decline in the posterior cingulate cortex (p≤0.05) and marginally in the frontal cortex (p=0.07).

conclusionsDiet influenced brain glucose metabolism in middle-aged participants, while plasma homocysteine explained variability in cognitive performance. These findings suggest that these modifiable risk factors affect AD risk through different pathways and support further investigation of risk reduction strategies in midlife.

Indexed as

AdultAlzheimer DiseaseAmyloid beta-PeptidesBiomarkersBrainBrain ChemistryDietGlucoseHomocysteineHumansLife StyleLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingAmyloid beta-PeptidesBiomarkersGlucoseHomocysteinealzheimer’s diseasebrain imagingdementialifestylemagnetic resonance imaging

Identifiers

PMID30478117
PMCPMC6254410

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.