Evidence map›Paper›PMID 30478034›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Dissociable Disruptions in Thalamic and Hippocampal Resting-State Functional Connectivity in Youth with 22q11.2 Deletions.

Charles Schleifer, Amy Lin, Leila Kushan, Jie Lisa Ji, Genevieve Yang, Carrie E Bearden, Alan Anticevic

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. The Associative Thalamus: A Switchboard for Cortical Operations and a Promising Target for Schizophrenia.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024
    Review
  14. Longitudinal Development of Thalamocortical Functional Connectivity in 22q11.2 Deletion Syndrome.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024
    Article
  15. Article
  16. Article
  17. Review
  18. The thalamus in psychosis spectrum disorder.Frontiers in neuroscience · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Charles SchleiferDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511.
Amy LinDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California 90095.ORCID 0000-0001-7757-6719
Leila KushanDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California 90095.
Jie Lisa JiDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511.ORCID 0000-0002-6280-9070
Genevieve YangDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511.
Carrie E BeardenDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California 90095, alan.anticevic@yale.edu cbearden@mednet.ucla.edu.ORCID 0000-0002-8516-923X
Alan AnticevicDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, alan.anticevic@yale.edu cbearden@mednet.ucla.edu.
Yale University · USUniversity of California, Los Angeles · US

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
UCLA Center for Translational Research in Neurodevelopment: UC-TRaNU54HD087101 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2016 to 2020
$6.5M
Neurodevelopment and Psychosis in the 22q11.2 Deletion SyndromeR01MH085953 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E · 2010 to 2020
$6.2M
Neurodevelopment and Psychosis in the 22q11.2 Copy Number VariantsR37MH085953 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARRIE E BEARDEN · 2023 to 2026
$2.9M
Training Grant in Neurobehavioral GeneticsT32MH073526 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, GESCHWIND, DANIEL H · 2006 to 2020
$2.4M
Characterizing Schizophrenia Progression via Multi-modal Neuroimaging and ComputationR01MH108590 · NIMH · YALE UNIVERSITY · PI ANTICEVIC, ALAN · 2016 to 2020
$2.0M
Characterizing Cognitive Impairment in Schizophrenia via Computational Modeling aDP5OD012109 · OD · YALE UNIVERSITY · PI ANTICEVIC, ALAN · 2012 to 2016
$1.8M
Mapping the Longitudinal Neurobiology of Early-course SchizophreniaR01MH112189 · NIMH · YALE UNIVERSITY · PI ANTICEVIC, ALAN · 2017 to 2021
$939k
NIBIB NIH HHS U54 EB020403NICHD NIH HHS U54 HD087101NIH HHS DP5 OD012109NIMH NIH HHS R01 MH085953NIMH NIH HHS R01 MH108590NIMH NIH HHS R01 MH112189NIMH NIH HHS R37 MH085953NIMH NIH HHS T32 MH073526NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

The 22q11.2 deletion syndrome (22q11DS) is a recurrent copy number variant with high penetrance for developmental neuropsychiatric disorders. Study of individuals with 22q11DS therefore may offer key insights into neural mechanisms underlying such complex illnesses. Resting-state functional connectivity MRI studies in idiopathic schizophrenia have consistently revealed disruption of thalamic and hippocampal circuitry. Here, we sought to test whether this circuitry is similarly disrupted in the context of this genetic high-risk condition. To this end, resting-state functional connectivity patterns were assessed in a sample of human youth with 22q11DS (

Indexed as

AdolescentAdultAgingChildConnectomeDiGeorge SyndromeFemaleGray MatterHippocampusHumansMagnetic Resonance ImagingMaleNerve NetNeural PathwaysNeuroimagingSensorimotor Cortex22q11connectivityfMRIhippocampusnetworksthalamus

Identifiers

PMID30478034
PMCPMC6381244
OpenAlexW2949441455

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.