ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Locus Coeruleus Phasic, But Not Tonic, Activation Initiates Global Remapping in a Familiar Environment.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 90 citations in OpenAlex.
- Subanesthetic Ketamine Suppresses Locus Coeruleus-Mediated Alertness Effects: A 7T fMRI Study.The international journal of neuropsychopharmacology · 2024Trial
- Subcellular Localization of Dopamine D1 and D2 Receptors in the Mouse Hippocampus.The Journal of comparative neurology · 2026Article
- The relevance of context in memory tasks influences the magnitude of hippocampal remapping.Cell reports · 2025Article
- Blood oxygenation level-dependent responses in neuromodulatory nuclei and their associations with attention and memory across age groups.Neurobiology of aging · 2025Article
- Phase synchrony between prefrontal noradrenergic and cholinergic signals indexes inhibitory control.Nature communications · 2025Article
- Age-related differences in locus coeruleus intensity across a demographically diverse sample.Neurobiology of aging · 2025Article
- Locus coeruleus activation 'resets' hippocampal event representations and separates adjacent memories.bioRxiv : the preprint server for biology · 2025Article
- Event boundaries drive norepinephrine release and distinctive neural representations of space in the rodent hippocampus.bioRxiv : the preprint server for biology · 2024Article
- Article
- Overnight neuronal plasticity and adaptation to emotional distress.Nature reviews. Neuroscience · 2024Review
- Locus Ceruleus Dynamics Are Suppressed during Licking and Enhanced Postlicking Independent of Taste Novelty.eNeuro · 2024Article
- Frequency Specific Optogenetic Stimulation of the Locus Coeruleus Induces Task-Relevant Plasticity in the Motor Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Contextual memory engrams, and the neuromodulatory influence of the locus coeruleus.Frontiers in molecular neuroscience · 2024Review
- Regional and interhemispheric differences of neuronal representations in dentate gyrus and CA3 inferred from expression of zif268.Scientific reports · 2023Article
- Review
- Article
- Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Altered pattern separation in Goto-Kakizaki rats.Current research in neurobiology · 2023Article
- Article
- Reactivating hippocampal-mediated memories during reconsolidation to disrupt fear.Nature communications · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Locus coeruleus (LC) neurons, the source of hippocampal norepinephrine (NE), are activated by novelty and changes in environmental contingencies. Based on the role of monoamines in reconfiguring invertebrate networks, and data from mammalian systems, a network reset hypothesis for the effects of LC activation has been proposed. We used the cellular compartmental analysis of temporal FISH technique based on the cellular distribution of immediate early genes to examine the effect of LC activation and inactivation, on regional hippocampal maps in male rats, when LC activity was manipulated just before placement in a second familiar (A/A) and/or novel environment (A/B). We found that bilateral phasic, but not tonic, activation of LC reset hippocampal maps in the A/A condition, whereas silencing the LC with clonidine before placement in the A/B condition blocked map reset and a familiar map emerged in the dentate gyrus, proximal and distal CA1, and CA3c. However, CA3a and CA3b encoded the novel environment. These results support a role for phasic LC responses in generating novel hippocampal sequences during memory encoding and, potentially, memory updating. The silencing experiments suggest that novel environments may not be recognized as different by dentate gyrus and CA1 without LC input. The functional distinction between phasic and tonic LC activity argues that these parameters are critical for determining network changes. These data are consistent with the hippocampus activating internal network representations to encode novel experiential episodes and suggest LC input is critical for this role.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.