Evidence map›Paper›PMID 30477815›Full record

ArticleEnvironment international2019

Cross-sectional associations between urinary triclosan and serum thyroid function biomarker concentrations in women.

Julianne Skarha, Lidia Mínguez-Alarcón, Paige L Williams, Tim I M Korevaar, Ralph A de Poortere, Maarten A C Broeren, Jennifer B Ford, Melissa Eliot, Russ Hauser, Joseph M Braun

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
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  9. Review
  10. Triclosan: A Small Molecule with Controversial Roles.Antibiotics (Basel, Switzerland) · 2022
    Review
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  19. Impact of prenatal triclosan exposure on gestational age and anthropometric measures at birth: A systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Julianne SkarhaDepartment of Epidemiology, Brown University, Providence, RI, USA.
Lidia Mínguez-AlarcónDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Paige L WilliamsDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Tim I M KorevaarDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Ralph A de PoortereLaboratory of Clinical Chemistry and Haematology, Máxima Medical Centre, De Run 4600, 5500 MB Veldhoven, the Netherlands.
Maarten A C BroerenLaboratory of Clinical Chemistry and Haematology, Máxima Medical Centre, De Run 4600, 5500 MB Veldhoven, the Netherlands.
Jennifer B FordDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Melissa EliotDepartment of Epidemiology, Brown University, Providence, RI, USA.
Russ HauserDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Joseph M BraunDepartment of Epidemiology, Brown University, Providence, RI, USA. Electronic address: joseph_braun_1@brown.edu.
Harvard University · USBrown University · USRadboud University Nijmegen · NL

Funding

Maternal and Paternal Preconception Environmental Exposures and Children's HealthR01ES027408 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BRAUN, JOSEPH M, HAUSER, RUSS B · 2018 to 2022
$3.0M
Endocrine Disrupting Chemicals, Thyroid Hormones, and Child NeurobehaviorR01ES024381 · NIEHS · BROWN UNIVERSITY · PI BRAUN, JOSEPH M · 2015 to 2018
$2.4M
NIEHS NIH HHS R01 ES024381NIEHS NIH HHS R01 ES027408
6 · The paper itself

Abstract

introductionExposure to the antimicrobial agent triclosan is ubiquitous. Research in animals shows that triclosan can cause decreases in thyroxine concentrations. However, the potential effects of triclosan on thyroid function in humans are unclear.

objectiveTo estimate the association between urinary triclosan concentrations and serum thyroid function biomarkers in women seeking assisted reproduction treatment in the Environment and Reproductive Health (EARTH) Study.

methodsWe conducted a cross-sectional study of 317 women enrolled in the EARTH Study, a prospective preconception cohort that recruits Boston area couples. Using samples collected at study entry, we quantified urinary triclosan and serum thyroid function biomarker concentrations, specifically free and total thyroxine and triiodothyronine, thyroid-stimulating hormone (TSH), and thyroid antibodies. We estimated covariate-adjusted differences in thyroid function biomarkers per 10-fold increase in triclosan using linear regression models. We examined effect modification by body mass index (BMI) and infertility diagnosis.

resultsThe median urinary triclosan concentration was 7.8 μg/L (IQR: 3.0-59 μg/L). Each 10-fold increase in triclosan was inversely associated with free triidothyronine (T

conclusionUrinary triclosan concentrations were inversely associated with specific serum thyroid function biomarkers in this cohort, suggesting that triclosan may affect thyroid homeostasis and autoimmunity.

Indexed as

AutoantibodiesBiomarkersBostonCross-Sectional StudiesFemaleHumansProspective StudiesThyrotropinTriclosananti-thyroglobulinAutoantibodiesBiomarkersThyrotropinTriclosanEndocrine disrupting chemicalsEpidemiologyThyroid hormonesTriclosanWomen

Identifiers

PMID30477815
PMCPMC6317095
OpenAlexW2900906275

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.