ArticleJournal of neuroinflammation2018
Inflammation is correlated with severity and outcome of cerebral venous thrombosis.
Article in Journal of neuroinflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Key prognostic risk factors linked to poor functional outcomes in cerebral venous sinus thrombosis: a systematic review and meta-analysis.BMC neurology · 2025Pooled it
- Inflammatory biomarkers in cerebral venous thrombosis versus ischemic stroke: a network meta-analysis.Frontiers in neurology · 2025Pooled it
- Clinical Significance of Baseline Neutrophil-to-Lymphocyte Ratio in Patients With Ischemic Stroke or Hemorrhagic Stroke: An Updated Meta-Analysis.Frontiers in neurology · 2019Pooled it
- Correlation Analysis of Coagulation and Platelet Parameters with Clinical Outcomes in Rheumatoid Arthritis Patients and the Interventional Effect of Jianpi Huashi Tongluo Formula - Xinfeng Capsule: A Post Hoc Analysis Based on an Randomized Controlled Trial.Drug design, development and therapy · 2025Trial
- Changes in Immune-Inflammation Status and Prognosis in Pregnancy-Related Cerebral Venous Thrombosis.Annals of clinical and translational neurology · 2026Article
- Glucocorticoids combined with anticoagulation modulate the central NLRP3/NETosis inflammatory process in patients with severe cerebral venous thrombosis: a human mechanistic exploratory study.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Predicting 3-month prognosis of cerebral venous thrombosis: a machine learning approach incorporating inflammatory markers.Frontiers in neurology · 2026Article
- Treatment of increased intracranial pressure secondary to otitic hydrocephalus.Frontiers in pediatrics · 2026Article
- The Joint Effect of C-Reactive Protein and Fibrinogen in Predicting Intracranial Hypertension of Cerebral Venous Sinus Thrombosis Patients.Journal of inflammation research · 2026Article
- Meningeal lymphatic vessel dysfunction exacerbates brain injury in CVST mice via endoplasmic reticulum and oxidative stress pathways.Frontiers in immunology · 2026Article
- Inflammatory markers and clinical outcomes in acute/subacute severe cerebral venous thrombosis: the role of glucocorticoid therapy.BMC neurology · 2025Article
- Predictive Value of Combined CRP and INR for Intracranial Hypertension in Cerebral Venous Thrombosis.Immunity, inflammation and disease · 2025Article
- Steroids combined with anticoagulant in acute/subacute severe cerebral venous thrombosis.Chinese medical journal · 2025Observational
- Steroids' Neuroprotective Potential in Severe Cerebral Venous Thrombosis: Experimental and Clinical Exploration of NLRP3 Inflammasome Inhibition.CNS neuroscience & therapeutics · 2024Article
- Expression and metabolism profiles of CVT associated with inflammatory responses and oxygen carrier ability in the brain.CNS neuroscience & therapeutics · 2024Article
- Association between inflammatory biomarkers and venous thromboembolism: a systematic review and meta-analysis.Thrombosis journal · 2023Review
- C-reactive protein and D-dimer in cerebral vein thrombosis: Relation to clinical and imaging characteristics as well as outcomes in a French cohort study.Research and practice in thrombosis and haemostasis · 2023Article
- Clinical characteristics of cerebral venous sinus thrombosis patients with new-onset of headache.BMC neurology · 2023Article
- Association of neutrophil to lymphocyte ratio and D-dimer with functional outcome in patients with cerebral venous sinus thrombosis.BMC neurology · 2023Article
- Prediction Score for Clinical Outcome of Chinese Patients with Cerebral Venous Thrombosis.International journal of general medicine · 2023Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFew studies have suggested a relationship between inflammation and cerebral venous thrombosis (CVT). This retrospective study aimed to explore the changes in inflammation in different CVT stages and the correlation between inflammation and severity and outcome of CVT.
methodsIn total, 95 suitable patients with CVT and 41 controls were compared. Patients with CVT were divided into three groups. The inflammatory factors studied included hypersensitive C-reactive protein (Hs-CRP), interleukin-6 (IL-6), and neutrophil-to-lymphocyte ratio (NLR) in the peripheral blood and immunoglobulin A (IgA), immunoglobulin M (IgM), and immunoglobulin G (IgG) in the cerebrospinal fluid (CSF). The severity of CVT was evaluated with the modified Rankin Scale (mRS), the National Institutes of Health Stroke Scale (NIHSS), fundus condition, intracranial pressure (ICP), and complications on admission. The short-term outcome was evaluated with the mRS at discharge.
resultsThe following results were obtained: (1) Inflammatory factor levels in patients with CVT were higher than those in the controls. (2) Inflammatory factor levels in the acute and subacute stages were significantly higher than those in the chronic stage (all P < 0.05). (3) Serum NLR and CSF IgM levels were positively related to baseline degree of disability (odds ratio [OR], 1.279, 95% confidence interval [CI] 1.009-1.621, P = 0.042; OR 1.402, 95% CI 1.036-1.896, P = 0.028). The Hs-CRP level was positively correlated with the baseline occurrence of seizure (OR 1.040, 95% CI 1.001-1.080, P = 0.043). The baseline serum NLR (r = 0.244, P = 0.017), CSF IgA (r = 0.615, P < 0.001), CSF IgM (r = 0.752, P < 0.001), and CSF IgG (r = 0.248, P = 0.015) levels were positively associated with NIHSS. (4) The baseline NLR was significantly associated with high risk of poor outcome at discharge (OR 1.339, 95% CI 1.097-1.784, P = 0.007). Moreover, the ROC showed that NLR ≥ 4.205 could better predict the poor outcome at discharge. The data were analyzed using SPSS.
conclusionsInflammation may develop after CVT and gradually decrease during the course. Inflammation was significantly correlated with severity on admission and short-term poor outcome at discharge in CVT.
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