Evidence map›Paper›PMID 30477461›Full record

ArticleBMC cancer2018

Flavonoids modulate multidrug resistance through wnt signaling in P-glycoprotein overexpressing cell lines.

S Mohana, M Ganesan, N Rajendra Prasad, D Ananthakrishnan, D Velmurugan

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Exploring the Protective Effect and Mechanism ofEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  5. Article
  6. Article
  7. Nobiletin Inhibits Non-Small-Cell Lung Cancer by Inactivating WNT/Evidence-based complementary and alternative medicine : eCAM · 2021
    Article
  8. Article
  9. Plants (Basel, Switzerland) · 2020
    Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

S MohanaDepartment of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, Tamil Nadu, 608 002, India.
M GanesanDepartment of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, Tamil Nadu, 608 002, India.
N Rajendra PrasadDepartment of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, Tamil Nadu, 608 002, India. drprasadnr@gmail.com.
D AnanthakrishnanBioinformatics Infrastructure Facility (BIF), University of Madras, Guindy Campus, Chennai, Tamil Nadu, India.
D VelmuruganBioinformatics Infrastructure Facility (BIF), University of Madras, Guindy Campus, Chennai, Tamil Nadu, India.
Annamalai University · INUniversity of Madras · IN

Funding

Indian Council of Medical Research 45/6/2014/HAE-BMSScience and Engineering Research Board SB/EMEQ-504/2014Science and Engineering Research Board SR/SO/BB-0034/2012
6 · The paper itself

Abstract

backgroundWnt signaling has been linked with P-glycoprotein (P-gp) overexpression and which was mainly mediated by β-catenin nuclear translocation. Flavonoids have already been reported as modulators of the Wnt/β-catenin pathway and hence they may serve as promising agents in the reversal of P-gp mediated cancer multi drug resistance (MDR).

methodsIn this study, we screened selected flavonoids against Wnt/β-catenin signaling molecules. The binding interaction of flavonoids (theaflavin, quercetin, rutin, epicatechin 3 gallate and tamarixetin) with GSK 3β was determined by molecular docking. Flavonoids on P-gp expression and the components of Wnt signaling in drug-resistant KBCH

resultsIn this study, we observed that the components of Wnt/β-catenin pathway such as Wnt and GSK 3β were activated in multidrug resistant KBCH

conclusionThe present findings illustrate that the studied flavonoids significantly enhances doxorubicin-mediated cell death through modulating P-gp expression pattern by targeting Wnt/β-catenin signaling in drug-resistant KBCH

Indexed as

Gene ExpressionApoptosisATP Binding Cassette Transporter, Subfamily B, Member 1Binding SitesCell Line, TumorDrug Resistance, MultipleDrug Resistance, NeoplasmFlavonoidsGlycogen Synthase Kinase 3 betaHumansModels, BiologicalMolecular ConformationProtein BindingStructure-Activity RelationshipWnt Signaling PathwayATP Binding Cassette Transporter, Subfamily B, Member 1FlavonoidsGlycogen Synthase Kinase 3 betaFlavonoidsGSK 3βMolecular dockingMultidrug resistanceP-glycoproteinWnt/β-catenin signaling

Identifiers

PMID30477461
PMCPMC6260573
OpenAlexW2902039250

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.