Evidence map›Paper›PMID 30477436›Full record

ArticleBMC neurology2018

The Norwegian Cognitive impairment after stroke study (Nor-COAST): study protocol of a multicentre, prospective cohort study.

Pernille Thingstad, Torunn Askim, Mona K Beyer, Geir Bråthen, Hanne Ellekjær, Hege Ihle-Hansen, Anne Brita Knapskog, Stian Lydersen, Ragnhild Munthe-Kaas, Halvor Næss and 3 more

Registry-linked trialOpen access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02650531 (Norwegian COgnitive Impairment After STroke), which is not on this map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02650531 completednot on this map

Norwegian COgnitive Impairment After STroke (NorCOAST) Study

TypeobservationalSponsorNorwegian University of Science and TechnologyRan2015 to 2018Enrolled816ConditionsDementia, Mild Cognitive Impairment, Stroke
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 67 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Pernille ThingstadDepartment of Neuromedicine and Movement Science, Faculty of Medicine and Health Science, NTNU Norwegian University of Science and Technology, Trondheim, Norway. pernille.thingstad@ntnu.no.ORCID http://orcid.org/0000-0002-9950-3657
Torunn AskimDepartment of Neuromedicine and Movement Science, Faculty of Medicine and Health Science, NTNU Norwegian University of Science and Technology, Trondheim, Norway.
Mona K BeyerDepartment of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Geir BråthenDepartment of Neuromedicine and Movement Science, Faculty of Medicine and Health Science, NTNU Norwegian University of Science and Technology, Trondheim, Norway.
Hanne EllekjærDepartment of Neuromedicine and Movement Science, Faculty of Medicine and Health Science, NTNU Norwegian University of Science and Technology, Trondheim, Norway.
Hege Ihle-HansenDepartment of Geriatrics, Oslo University Hospital, Oslo, Norway.
Anne Brita KnapskogDepartment of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.
Stian LydersenDepartment of Mental Health, Faculty of Medicine, Regional Centre for Child and Youth Mental Health and Child Care, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
Ragnhild Munthe-KaasDepartment of Medicine, Vestre Viken Hospital Trust, Bærum Hospital, Drammen, Norway.
Halvor NæssDepartment of neurology, Haukeland University Hospital, Bergen, Norway.
Sarah T PendleburyCentre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Yngve Muller SeljesethMedical Department, Ålesund Hospital, Møre and Romsdal Health Trust, Ålesund, Norway.
Ingvild SaltvedtDepartment of Neuromedicine and Movement Science, Faculty of Medicine and Health Science, NTNU Norwegian University of Science and Technology, Trondheim, Norway.
Norwegian University of Science and Technology · NOOslo University Hospital · NOÅlesund Hospital · NOJohn Radcliffe Hospital · GBStavanger University Hospital · NOVestre Viken Hospital Trust · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly and late onset post-stroke cognitive impairment (PCI) contributes substantially to disability following stroke, and is a high priority within stroke research. The aetiology for PCI is complex and related to the stroke itself, brain resilience, comorbid brain diseases, prestroke vulnerability and complications during the hospital stay. The aim of the Norwegian Cognitive Impairment After Stroke study (Nor-COAST) is to quantify and measure levels of cognitive impairments in a general Norwegian stroke population and to identify biological and clinical markers associated with prognosis for cognitive disorders following incident stroke. The study will be organised within five work packages: 1) Incidence and trajectories 2) Pathological mechanisms 3) Development of a risk score 4) Impact of physical activity and 5) Adherence to secondary prevention.

methodsNor-COAST is an ongoing multicentre (five participating hospitals), prospective, cohort study with consecutive inclusion during the acute phase and with follow-up at three and 18 months, and at three years. Inclusion criteria are stroke defined according to the WHO criteria. During the recruitment period from 18.05.2015 to 31.03.2017, 816 participants have been included. Cognitive impairment will be classified according to the DSM-5 criteria using a consensus group. Cognitive function is assessed by a standardised neuropsychological test battery, the Montreal Cognitive Assessment, Trail making A and B, ten-word immediate and delayed recall test, the Controlled Oral Word Association, Global Deterioration Scale and proxy based information by and the Ascertain Dementia 8 item informant questionnaire. Biomarkers include magnetic resonance imaging, routine blood samples and bio-banking. Clinical assessments include characteristics of the stroke, comorbidity, delirium, frailty and tests for cognitive and physical function, sensor based activity monitoring and adherence to secondary prophylaxis. DISCUSSION: Nor-COAST is the first Norwegian multicentre study to quantify burden of PCI that will provide reliable estimates in a general stroke population. A multidisciplinary approach aiming to identify biomarkers and clinical markers of overall prognosis will add new knowledge about risk profiles, including pre-stroke vulnerability and modifiable factors such as physical activity and secondary prophylaxis of relevance for clinical practice and later intervention studies.

trial registrationClinicalTrials.gov: NCT02650531 . Retrospectively registered January 8, 2016. First participant included May 18, 2015.

Indexed as

AgedBiomarkersCognitive DysfunctionCohort StudiesFemaleHumansMaleProspective StudiesResearch DesignStrokeBiomarkersCerebrovascular disordersDementiaMild cognitive impairmentPost-stroke cognitive impairmentPrevalenceStroke

Identifiers

PMID30477436
PMCPMC6260901
OpenAlexW2902641543

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.