ArticleMolecules (Basel, Switzerland)2018
Raman Spectroscopic Analysis to Detect Reduced Bone Quality after Sciatic Neurectomy in Mice.
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Bone Quality Heterogeneity in Mixed Femoral Metastases Revealed by Stimulated Raman Scattering Spectromicroscopy.Annals of biomedical engineering · 2026Article
- Distinct Spectral Profiles of Pleural Effusions from Malignant Tumors Using Raman Spectroscopy.International journal of molecular sciences · 2025Article
- Article
- Pharmacological inhibition of endoplasmic reticulum stress mitigates osteoporosis in a mouse model of hindlimb suspension.Scientific reports · 2024Article
- Label-Free, Noninvasive Bone Cell Classification by Hyperspectral Confocal Raman Microscopy.Chemical & biomedical imaging · 2024Article
- Machine learning enabled multiplex detection of periodontal pathogens by surface-enhanced Raman spectroscopy.International journal of biological macromolecules · 2024Article
- Multifunctional 3D matrixes based on flexible bioglass nanofibers for potential application in postoperative therapy of osteosarcoma.Regenerative biomaterials · 2024Article
- Practices, Potential, and Perspectives for Detecting Predisease Using Raman Spectroscopy.International journal of molecular sciences · 2023Review
- Article
- Running exercise and food restriction affect bone chemical properties in young female rats.Physical activity and nutrition · 2023Article
- Application of the Dynamical Network Biomarker Theory to Raman Spectra.Biomolecules · 2022Article
- Prognostic potential and pathological validation of a diagnostic application using Raman spectroscopy in the characterization of degenerative changes in the cartilage of the humeral head.Journal of biomedical optics · 2022Article
- Raman Spectra and Ancient Life: Vibrational ID Profiles of Fossilized (Bone) Tissues.International journal of molecular sciences · 2022Article
- Similarities Between Disuse and Age-Induced Bone Loss.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Review
- Low Turnover Renal Osteodystrophy With Abnormal Bone Quality and Vascular Calcification in Patients With Mild-to-Moderate CKD.Kidney international reports · 2022Article
- Comparative Properties of K/NaX and K/NaY from Ultrasound-Assisted Impregnation and Performance in Transesterification of Palm Oil.ACS omega · 2022Article
- Bone Quality and Fractures in Women With Osteoporosis Treated With Bisphosphonates for 1 to 14 Years.JBMR plus · 2021Article
- Breast cancer-secreted factors perturb murine bone growth in regions prone to metastasis.Science advances · 2021Article
- Electroacupuncture ameliorates intestinal inflammation by activating α7nAChR-mediated JAK2/STAT3 signaling pathway in postoperative ileus.Theranostics · 2021Article
- Determination of cadmium induced acute and chronic reproductive toxicity with Raman spectroscopy.Lasers in medical science · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Bone mineral density (BMD) is a commonly used diagnostic indicator for bone fracture risk in osteoporosis. Along with low BMD, bone fragility accounts for reduced bone quality in addition to low BMD, but there is no diagnostic method to directly assess the bone quality. In this study, we investigated changes in bone quality using the Raman spectroscopic technique. Sciatic neurectomy (NX) was performed in male C57/BL6J mice (NX group) as a model of disuse osteoporosis, and sham surgery was used as an experimental control (Sham group). Eight months after surgery, we acquired Raman spectral data from the anterior cortical surface of the proximal tibia. We also performed a BMD measurement and micro-CT measurement to investigate the pathogenesis of osteoporosis. Quantitative analysis based on the Raman peak intensities showed that the carbonate/phosphate ratio and the mineral/matrix ratio were significantly higher in the NX group than in the Sham group. There was direct evidence of alterations in the mineral content associated with mechanical properties of bone. To fully understand the spectral changes, we performed principal component analysis of the spectral dataset, focusing on the matrix content. In conclusion, Raman spectroscopy provides reliable information on chemical changes in both mineral and matrix contents, and it also identifies possible mechanisms of disuse osteoporosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.