Evidence map›Paper›PMID 30477235›Full record

ArticleViruses2018

A Novel Highly Divergent Strain of Cell Fusing Agent Virus (CFAV) in Mosquitoes from the Brazilian Amazon Region.

Licia Natal Fernandes, Thaís de Moura Coletti, Fred Julio Costa Monteiro, Marlisson Octavio da Silva Rego, Edcelha Soares D'Athaide Ribeiro, Geovani de Oliveira Ribeiro, Robson Dos Santos Souza Marinho, Shirley Vasconcelos Komninakis, Steven S Witkin, Xutao Deng and 4 more

Abstract read
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Viruses · 2020
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Licia Natal FernandesLaboratory of Protozoology, Institute of Tropical Medicine, University of São Paulo, São Paulo, SP 05403-000, Brazil. licianatal@usp.br.
Thaís de Moura ColettiLaboratory of Protozoology, Institute of Tropical Medicine, University of São Paulo, São Paulo, SP 05403-000, Brazil. thaiscoletti@gmail.com.
Fred Julio Costa MonteiroLaboratory of Vectors, Superintendence for the Health Survaillance of Amapá, Macapá, AP 68905-230, Brazil. fredjulio@gmail.com.
Marlisson Octavio da Silva RegoLaboratory of Vectors, Superintendence for the Health Survaillance of Amapá, Macapá, AP 68905-230, Brazil. farmarlisson@hotmail.com.
Edcelha Soares D'Athaide RibeiroLaboratory of Vectors, Superintendence for the Health Survaillance of Amapá, Macapá, AP 68905-230, Brazil. edcelhamanu@hotmail.com.
Geovani de Oliveira RibeiroInstitute of Biologycal Sciences, Federal University of Pará, Belém, Pará 66075-000, Brazil. geovanioribeiro@gmail.com.
Robson Dos Santos Souza MarinhoLaboratory of Retrovirology, Federal University of São Paulo, São Paulo, SP 04039-032, Brazil. elcioleal@gmail.com.
Shirley Vasconcelos KomninakisLaboratory of Retrovirology, Federal University of São Paulo, São Paulo, SP 04039-032, Brazil. skomninakis@yahoo.com.br.
Steven S WitkinDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA. robsonsantos@id.uff.br.
Xutao DengVitalant Research Institute, 270 Masonic Avenue, San Francisco, CA 94118-4417, USA. xdeng@vitalant.org.
Eric DelwartVitalant Research Institute, 270 Masonic Avenue, San Francisco, CA 94118-4417, USA. eric.delwart@ucsf.edu.
Ester Cerdeira SabinoInstitute of Tropical Medicine, University of São Paulo, São Paulo, SP 05403-000, Brazil. witkinss@gmail.com.
Élcio LealInstitute of Biologycal Sciences, Federal University of Pará, Belém, Pará 66075-000, Brazil. sabinoec@gmail.com.
Antonio Charlys da CostaInstitute of Tropical Medicine, University of São Paulo, São Paulo, SP 05403-000, Brazil. charlysbr@yahoo.com.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq 400354/2016-0FAPEAP/CNPq PPSUS 250.203.0333/2016Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/01735-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/00021-9Fundação de Amparo à Pesquisa do Estado de São Paulo FAPESP 2016/18204-0
6 · The paper itself

Abstract

Classical insect-specific flaviviruses (cISFs) have been widely detected in different countries in the last decades. Here, we characterize the near full-length genomes of two cISFs detected in mosquitoes collected in the city of Macapá, state of Amapá, Amazon region of Brazil. A total of 105 pools of female mosquitos were analyzed by next-generation sequencing (NGS). Comparative genomics and phylogenetic analysis identified three strains of cell fusing agent virus (CFAV) and two of Culex flavivirus (CxFV). All sequences were obtained from pools of Culex sp., except for one sequence of CFAV detected in a pool of Aedes aegypti. Both CxFV strains are phylogenetically related to a strain isolated in 2012 in the Southeast region of Brazil. The CFAV strains are the first of this species to be identified in Brazil and one of them is highly divergent from other strains of CFAV that have been detected worldwide. In conclusion, CFAV and CxFV, circulate in mosquitoes in Brazil. One strain of CFAV is highly divergent from others previously described, suggesting that a novel strain of CFAV is present in this region.

Indexed as

AnimalsBrazilCulicidaeEvolution, MolecularFlavivirusGenome, ViralHigh-Throughput Nucleotide SequencingPhylogenyTropical ClimateViral Nonstructural ProteinsNS5 protein, flavivirusViral Nonstructural ProteinsAmazon regioncell fusing agent virusCulex flavivirusCulex sp., Aedes aegyptiflavivirusmosquitoes

Identifiers

PMID30477235
PMCPMC6315449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.