Evidence map›Paper›PMID 30477208›Full record

ReviewJournal of personalized medicine2018

Applications of CRISPR/Cas9 for the Treatment of Duchenne Muscular Dystrophy.

Kenji Rowel Q Lim, Chantal Yoon, Toshifumi Yokota

Open access · goldAbstract readReview
In one paragraph

Review in Journal of personalized medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 70 citations in OpenAlex.

  1. CRISPR-Based Gene Therapy for Brain Disease.Molecular neurobiology · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. International journal of biological sciences · 2026
    Review
  6. Review
  7. MYH6-Cre Insertion Accelerates Cardiac Phenotype in Dystrophic D2-mdx Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  8. Review
  9. Review
  10. Article
  11. Genome Editing and Pathological Cardiac Hypertrophy.Advances in experimental medicine and biology · 2023
    Article
  12. Review
  13. Current Strategies of Muscular Dystrophy Therapeutics: An Overview.Methods in molecular biology (Clifton, N.J.) · 2023
    Review
  14. CRISPR Therapeutics for Duchenne Muscular Dystrophy.International journal of molecular sciences · 2022
    Review
  15. Article
  16. CRISPR technologies for the treatment of Duchenne muscular dystrophy.Molecular therapy : the journal of the American Society of Gene Therapy · 2021
    Review
  17. Article
  18. Review
  19. Article
  20. Toward the correction of muscular dystrophy by gene editing.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kenji Rowel Q LimDepartment of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, 8812-112 St., Edmonton, AB T6G 2H7, Canada. kenjirow@ualberta.ca.ORCID 0000-0002-5484-4183
Chantal YoonDepartment of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, 8812-112 St., Edmonton, AB T6G 2H7, Canada. cyoon@ualberta.ca.
Toshifumi YokotaDepartment of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, 8812-112 St., Edmonton, AB T6G 2H7, Canada. toshifum@ualberta.ca.ORCID 0000-0001-6672-6742
University of Alberta · CA

Funding

Canadian Institutes of Health Research FRN134134
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is a fatal X-linked recessive neuromuscular disease prevalent in 1 in 3500 to 5000 males worldwide. As a result of mutations that interrupt the reading frame of the

Indexed as

CRISPR/Cas9deltaE50-MD dog modelDuchenne muscular dystrophy (DMD)exon skipping therapygene editinghuman induced pluripotent stem cells (hiPSCs)humanized dystrophic mouse modelsimmortalized patient muscle cellsmdx mice

Identifiers

PMID30477208
PMCPMC6313657
OpenAlexW2900564760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.