Evidence map›Paper›PMID 30477147›Full record

ArticleMolecules (Basel, Switzerland)2018

Novel 5'-Norcarbocyclic Pyrimidine Derivatives as Antibacterial Agents.

Anastasia L Khandazhinskaya, Liudmila A Alexandrova, Elena S Matyugina, Pavel N Solyev, Olga V Efremenkova, Karen W Buckheit, Maggie Wilkinson, Robert W Buckheit, Larisa N Chernousova, Tatiana G Smirnova and 5 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Design and Synthesis of Novel Antimicrobial Agents.Antibiotics (Basel, Switzerland) · 2023
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Antibacterial Prodrugs to Overcome Bacterial Resistance.Molecules (Basel, Switzerland) · 2020
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Anastasia L KhandazhinskayaEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia. khandazhinskaya@bk.ru.
Liudmila A AlexandrovaEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia. ala2004_07@mail.ru.
Elena S MatyuginaEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia. matyugina@gmail.com.
Pavel N SolyevEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia. solyev@gmail.com.ORCID 0000-0002-5546-4975
Olga V EfremenkovaGause Institute of New Antibiotics, 11 Bol'shaya Pirogovskaya St., Moscow 119021, Russia. ovefr@yandex.ru.ORCID 0000-0003-3131-1031
Karen W BuckheitImQuest BioSciences, 7340 Executive Way Suite R, Frederick, MD 21704, USA. kbuckheit@imquestbio.com.
Maggie WilkinsonImQuest BioSciences, 7340 Executive Way Suite R, Frederick, MD 21704, USA. mwilkinson@imquestbio.com.
Robert W BuckheitImQuest BioSciences, 7340 Executive Way Suite R, Frederick, MD 21704, USA. rbuckheit@imquestbio.com.
Larisa N ChernousovaCentral Tuberculosis Research Institute, 2 Yauzskaya Alley, Moscow 107564, Russia. lchernousova@mail.ru.
Tatiana G SmirnovaCentral Tuberculosis Research Institute, 2 Yauzskaya Alley, Moscow 107564, Russia. s_tatka@mail.ru.
Sofya N AndreevskayaCentral Tuberculosis Research Institute, 2 Yauzskaya Alley, Moscow 107564, Russia. andsofia@mail.ru.
Olga G LeonovaEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia. varjag@aport2000.ru.
Vladimir I PopenkoEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia. popenko@eimb.ru.
Sergey N KochetkovEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia. kochet@eimb.ru.
Katherine L Seley-RadtkeDepartment of Chemistry & Biochemistry, University of Maryland, 1000 Hilltop Circle, Baltimore, MD 21250, USA. kseley@umbc.edu.ORCID 0000-0002-0154-3459

Funding

Russian Foundation for Basic Research № 14-50-00060
6 · The paper itself

Abstract

A series of novel 5'-norcarbocyclic derivatives of 5-alkoxymethyl or 5-alkyltriazolyl-methyl uracil were synthesized and the activity of the compounds evaluated against both Gram-positive and Gram-negative bacteria. The growth of

Indexed as

Anti-Bacterial AgentsAntitubercular AgentsHumansMicrobial Sensitivity TestsMolecular StructureMycobacterium tuberculosisPyrimidinesStructure-Activity RelationshipUracilAnti-Bacterial AgentsAntitubercular AgentsPyrimidinesUracil5′-norcarbocyclic nucleosidesantibacterial activityMycobacterium tuberculosisuracil derivatives

Identifiers

PMID30477147
PMCPMC6321083

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.