Evidence map›Paper›PMID 30477146›Full record

ArticleInternational journal of molecular sciences2018

Engineered Mesenchymal Stem Cells Expressing Stromal Cell-derived Factor-1 Improve Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats.

Seung Hwan Jeon, Guan Qun Zhu, Woong Jin Bae, Sae Woong Choi, Hyun Cheol Jeong, Hyuk Jin Cho, U-Syn Ha, Sung-Hoo Hong, Ji Youl Lee, Eun Bi Kwon and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Seung Hwan JeonDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. shwan52@naver.com.
Guan Qun ZhuDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. xiaoguanqun1@gmail.com.ORCID 0000-0001-7841-8026
Woong Jin BaeDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. bwoong@catholic.ac.kr.
Sae Woong ChoiDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. lifeisa9ame@catholic.ac.kr.
Hyun Cheol JeongDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. koulich@naver.com.
Hyuk Jin ChoDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. hyukjincho0403@gmail.com.
U-Syn HaDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. ushamd@catholic.ac.kr.
Sung-Hoo HongDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. toomey@catholic.ac.kr.
Ji Youl LeeDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. uroljy@catholic.ac.kr.
Eun Bi KwonDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. eunbi9859@naver.com.
Hyo-Jin KimDepartment of Stem cell therapy, SL BIGEN, Seongnam 13488, Korea. hjkim@slbigen.com.
Soon Min LeeDepartment of Stem cell therapy, SL BIGEN, Seongnam 13488, Korea. smlee@slbigen.com.
Hey-Yon KimDepartment of Stem cell therapy, SL BIGEN, Seongnam 13488, Korea. hykim@slbigen.com.
Sae Woong KimDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. ksw1227@catholic.ac.kr.
Catholic University of Korea · KR

Funding

This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science & ICT NRF-2018M3A9E8020861
6 · The paper itself

Abstract

Effective therapies for erectile dysfunction (ED) associated with diabetes mellitus (DM) are needed. In this study, the effects of stromal cell-derived factor-1 (SDF-1)-expressing engineered mesenchymal stem cells (SDF-1 eMSCs) and the relevant mechanisms in the corpus cavernosum of a streptozotocin (STZ)-induced DM ED rat model were evaluated. In a randomized controlled trial, Sprague⁻Dawley (SD) rats (

Indexed as

Gene ExpressionGenetic EngineeringMesenchymal Stem Cell TransplantationAnimalsBlood GlucoseBody WeightCell MovementChemokine CXCL12Diabetes Mellitus, ExperimentalDisease Models, AnimalErectile DysfunctionMaleMesenchymal Stem CellsNeovascularization, PhysiologicNitric Oxide Synthase Type INitric Oxide Synthase Type IIIBlood GlucoseChemokine CXCL12Nitric Oxide Synthase Type INitric Oxide Synthase Type IIIPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-akterectile dysfunctionintracavernosal injectionstreptozotocin-induced diabetic ratsstromal cell-derived factor-1 expressing engineered mesenchymal stem cells

Identifiers

PMID30477146
PMCPMC6321323
OpenAlexW2901505320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.