Evidence map›Paper›PMID 30477110›Full record

ArticleJournal of clinical medicine2018

Fatigue is Highly Prevalent in Patients with Asthma and Contributes to the Burden of Disease.

Maarten Van Herck, Martijn A Spruit, Chris Burtin, Remco Djamin, Jeanine Antons, Yvonne M J Goërtz, Zjala Ebadi, Daisy J A Janssen, Jan H Vercoulen, Jeannette B Peters and 7 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. The effect of graded exercise therapy on fatigue in people with serious respiratory illness: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2024
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Breathlessness in the general population.Current opinion in supportive and palliative care · 2025
    Review
  7. Patient-centred outcomes in severe asthma: fatigue, sleep, physical activity and work.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  8. Evidence-based management of symptoms in serious respiratory illness: what is in our toolbox?European respiratory review : an official journal of the European Respiratory Society · 2024
    Article
  9. Article
  10. Article
  11. Prognostic factors for persistent fatigue after COVID-19: a prospective matched cohort study in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2023
    Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 3 countries.

Maarten Van HerckREVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Rehabilitation Sciences, Hasselt University, 3590 Diepenbeek, Belgium. maarten.vanherck@uhasselt.be.ORCID 0000-0002-3333-6964
Martijn A SpruitREVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Rehabilitation Sciences, Hasselt University, 3590 Diepenbeek, Belgium. martijnspruit@ciro-horn.nl.ORCID 0000-0003-3822-7430
Chris BurtinREVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Rehabilitation Sciences, Hasselt University, 3590 Diepenbeek, Belgium. chris.burtin@uhasselt.be.
Remco DjaminDepartment of Respiratory Medicine, Amphia Hospital, 4818 CK Breda, The Netherlands. rdjamin@amphia.nl.ORCID 0000-0002-4522-5532
Jeanine AntonsDepartment of Pulmonary Medicine, Radboud University Medical Center (Radboudumc), 6525 GA Nijmegen, The Netherlands. jeanine.antons@radboudumc.nl.
Yvonne M J GoërtzDepartment of Research and Education, CIRO, Centre of Expertise for Chronic Organ Failure, 6085 NM Horn, The Netherlands. yvonnegoertz@ciro-horn.nl.
Zjala EbadiDepartment of Medical Psychology, Radboudumc, 6525 GA Nijmegen, The Netherlands. zjala.ebadi@radboudumc.nl.
Daisy J A JanssenDepartment of Research and Education, CIRO, Centre of Expertise for Chronic Organ Failure, 6085 NM Horn, The Netherlands. daisyjanssen@ciro-horn.nl.
Jan H VercoulenDepartment of Medical Psychology, Radboudumc, 6525 GA Nijmegen, The Netherlands. jan.vercoulen@radboudumc.nl.
Jeannette B PetersDepartment of Medical Psychology, Radboudumc, 6525 GA Nijmegen, The Netherlands. jeannette.jacobs-peters@radboudumc.nl.
Melissa S Y ThongDepartment of Medical Psychology, Amsterdam University Medical Centers, location AMC, 1105 AZ Amsterdam, The Netherlands. s.y.thong@amc.uva.nl.
Jacqueline OtkerMember of Lung Foundation Netherlands, 3818 LE Amersfoort, The Netherlands. jmotker@telfort.nl.
Arnold CoorsMember of Patient Advisory Board, Radboudumc, 6525 GA Nijmegen, The Netherlands. arnoldcoors@mac.com.
Mirjam A G SprangersDepartment of Medical Psychology, Amsterdam University Medical Centers, location AMC, 1105 AZ Amsterdam, The Netherlands. m.a.sprangers@amc.uva.nl.
Jean W M MurisDepartment of General Practice, MUMC+, 6229 HX Maastricht, The Netherlands. jean.muris@maastrichtuniversity.nl.ORCID 0000-0002-8780-476X
Emiel F M WoutersDepartment of Research and Education, CIRO, Centre of Expertise for Chronic Organ Failure, 6085 NM Horn, The Netherlands. ewouters@ciro-horn.nl.
Alex J van 't HulDepartment of Pulmonary Medicine, Radboud University Medical Center (Radboudumc), 6525 GA Nijmegen, The Netherlands. alex.vanthul@radboudumc.nl.ORCID 0000-0002-5514-2327
Radboud University Nijmegen · NLAmsterdam University Medical Centers · NLCiro · NLMaastricht University · NLMaastricht University Medical Centre · NLAmphia Ziekenhuis · NLHasselt University · BELung Foundation Netherlands · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 2018 update of the Global Strategy for Asthma Management and Prevention does not mention fatigue-related symptoms. Nevertheless, patients with asthma frequently report tiredness, lack of energy, and daytime sleepiness. Quantitative research regarding the prevalence of fatigue in asthmatic patients is lacking. This retrospective cross-sectional study of outpatients with asthma upon referral to a chest physician assessed fatigue (Checklist Individual Strength-Fatigue (CIS-Fatigue)), lung function (spirometry), asthma control (Asthma Control Questionnaire (ACQ)), dyspnea (Medical Research Council (MRC) scale), exercise capacity (six-minute walk test (6MWT)), and asthma-related Quality-of-Life (QoL), Asthma Quality of Life Questionnaire (AQLQ) during a comprehensive health-status assessment. In total, 733 asthmatic patients were eligible and analyzed (47.4 ± 16.3 years, 41.1% male). Severe fatigue (CIS-Fatigue ≥ 36 points) was detected in 62.6% of patients. Fatigue was not related to airflow limitation (FEV1,

Indexed as

asthmafatiguequality of life

Identifiers

PMID30477110
PMCPMC6306949
OpenAlexW2900619686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.