Evidence map›Paper›PMID 30476227›Full record

ArticleNucleic acids research2019

The BioGRID interaction database: 2019 update.

Rose Oughtred, Chris Stark, Bobby-Joe Breitkreutz, Jennifer Rust, Lorrie Boucher, Christie Chang, Nadine Kolas, Lara O'Donnell, Genie Leung, Rochelle McAdam and 7 more

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 785 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
785citing papers in PubMed, 1 pooled it
74.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

785 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,586 citations in OpenAlex.

  1. Pooled it
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725 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Rose OughtredLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Chris StarkThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Bobby-Joe BreitkreutzThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Jennifer RustLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Lorrie BoucherThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Christie ChangLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Nadine KolasThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Lara O'DonnellThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Genie LeungThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Rochelle McAdamArthur and Sonia Labatt Brain Tumor Research Center and Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.
Frederick ZhangArthur and Sonia Labatt Brain Tumor Research Center and Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.
Sonam DolmaArthur and Sonia Labatt Brain Tumor Research Center and Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.
Andrew WillemsThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Jasmin Coulombe-HuntingtonInstitute for Research in Immunology and Cancer, Université de Montréal, Montréal, Quebec H3C 3J7, Canada.
Andrew Chatr-AryamontriInstitute for Research in Immunology and Cancer, Université de Montréal, Montréal, Quebec H3C 3J7, Canada.
Kara DolinskiLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Mike TyersThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Mount Sinai Hospital · CAPrinceton University · USHospital for Sick Children · CAInstitute for Research in Immunology and Cancer · CA

Funding

BioGRID: An open resource for biological interactions and network analysisR01OD010929 · OD · SINAI HEALTH SYSTEM · PI KARA DOLINSKI, Mike Tyers · 2012 to 2026
$13.9M
Biomedical Data Translator Technical Feasibility Assessment and Architecture DesignOT3TR002026 · NCATS · INSTITUTE FOR SYSTEMS BIOLOGY · PI GLUSMAN, GWÊNLYN, HUANG, SUI · 2016 to 2019
$3.3M
Biotechnology and Biological Sciences Research Council BB/F010486/1NCATS NIH HHS OT3 TR002026NIH HHS R01 OD010929
6 · The paper itself

Abstract

The Biological General Repository for Interaction Datasets (BioGRID: https://thebiogrid.org) is an open access database dedicated to the curation and archival storage of protein, genetic and chemical interactions for all major model organism species and humans. As of September 2018 (build 3.4.164), BioGRID contains records for 1 598 688 biological interactions manually annotated from 55 809 publications for 71 species, as classified by an updated set of controlled vocabularies for experimental detection methods. BioGRID also houses records for >700 000 post-translational modification sites. BioGRID now captures chemical interaction data, including chemical-protein interactions for human drug targets drawn from the DrugBank database and manually curated bioactive compounds reported in the literature. A new dedicated aspect of BioGRID annotates genome-wide CRISPR/Cas9-based screens that report gene-phenotype and gene-gene relationships. An extension of the BioGRID resource called the Open Repository for CRISPR Screens (ORCS) database (https://orcs.thebiogrid.org) currently contains over 500 genome-wide screens carried out in human or mouse cell lines. All data in BioGRID is made freely available without restriction, is directly downloadable in standard formats and can be readily incorporated into existing applications via our web service platforms. BioGRID data are also freely distributed through partner model organism databases and meta-databases.

Indexed as

Databases, FactualAnimalsCRISPR-Cas SystemsData CurationDrug DiscoveryGenesHumansMiceProtein Interaction Mapping

Identifiers

PMID30476227
PMCPMC6324058
OpenAlexW2917858269

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.