Evidence map›Paper›PMID 30476125›Full record

ReviewThe Journal of infectious diseases2019

Undernutrition and Tuberculosis: Public Health Implications.

Pranay Sinha, Juliana Davis, Lauren Saag, Christine Wanke, Padmini Salgame, Jackson Mesick, C Robert Horsburgh, Natasha S Hochberg

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 3 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 3 syntheses or guidelines pooled it, 196 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Energy dense nutritional supplements improve weight gain among malnourished adults with drug-sensitive pulmonary tuberculosis: An open-label randomized controlled trial in Faridabad, India.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
    Trial
  5. The Impact of Vitamin A Deficiency on Tuberculosis Progression.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Trial
  6. Review
  7. Molecular Characterization of theAntibiotics (Basel, Switzerland) · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Pranay SinhaSection of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Massachusetts.
Juliana DavisDepartment of Epidemiology, Boston University School of Public Health, Massachusetts.
Lauren SaagDivision of Epidemiology, Vanderbilt University, Nashville, Tennessee.
Christine WankeTufts University School of Medicine, Boston, Massachusetts.
Padmini SalgameCentre for Emerging Pathogens, Department of Medicine, Rutgers-New Jersey Medical School, Newark.
Jackson MesickDepartment of Epidemiology, Boston University School of Public Health, Massachusetts.
C Robert HorsburghSection of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Massachusetts.
Natasha S HochbergSection of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Massachusetts.
Boston University · USRutgers New Jersey Medical SchoolTufts University · USVanderbilt University · US

Funding

Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3M
Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI LARRY K BROWN · 1998 to 2026
$51.7M
Validation and Application of a Model for Human-like TB Latency in RabbitsU19AI111276 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI ALLAND, DAVID, ALLAND, DAVID · 2014 to 2020
$23.3M
NRSA Training CoreTL1TR002244 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2017 to 2026
$4.6M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)TL1TR000447 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$1.2M
NCATS NIH HHS TL1 TR000447NCATS NIH HHS TL1 TR002244NCATS NIH HHS UL1 TR001430NIAID NIH HHS P30 AI042853NIAID NIH HHS U19 AI111276
6 · The paper itself

Abstract

Almost 800 million people are chronically undernourished worldwide, of whom 98% are in low- and middle-income countries where tuberculosis is endemic. In many tuberculosis-endemic countries, undernutrition is a driver of tuberculosis incidence and associated with a high population attributable fraction of tuberculosis and poor treatment outcomes. Data suggest that undernutrition impairs innate and adaptive immune responses needed to control Mycobacterium tuberculosis infection and may affect responses to live vaccines, such as BCG. Given its impact on tuberculosis, addressing undernutrition will be a vital component of the World Health Organization End TB strategy. This narrative review describes the effect of undernutrition on the immune response, vaccine response, and tuberculosis incidence, severity, and treatment outcomes.

Indexed as

ComorbidityDietary SupplementsHumansIncidenceMalnutritionMycobacterium tuberculosisNutrientsNutrition AssessmentPublic HealthSeverity of Illness IndexTreatment OutcomeTuberculosis, PulmonaryVaccinesNutrientsVaccinesbody mass indexlatent Mycobacterium tuberculosis infectionnutrition disorderstuberculosisUndernutrition

Identifiers

PMID30476125
PMCPMC6941617
OpenAlexW2901109511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.