ArticlePathogens and disease2018
Protective vascular coagulation in response to bacterial infection of the kidney is regulated by bacterial lipid A and host CD147.
Article in Pathogens and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Targeting cancer-derived extracellular vesicles by combining CD147 inhibition with tissue factor pathway inhibitor for the management of urothelial cancer cells.Cell communication and signaling : CCS · 2024Article
- Bystander effect of SARS-CoV-2 spike protein on human monocytic THP-1 cell activation and initiation of prothrombogenic stimulus representing severe COVID-19.Journal of inflammation (London, England) · 2022Article
- Effect of anticoagulant and platelet inhibition on the risk of bacteremia among patients with acute pyelonephritis: a retrospective cohort study.BMC infectious diseases · 2022Article
- Plasma tissue factor coagulation activity in post-acute myocardial infarction patients.Frontiers in endocrinology · 2022Article
- Intravital Multiphoton Microscopy as a Tool for Studying Renal Physiology, Pathophysiology and Therapeutics.Frontiers in physiology · 2022Review
- UPEC kidney infection triggers neuro-immune communication leading to modulation of local renal inflammation by splenic IFNγ.PLoS pathogens · 2021Article
- Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Investigation of CD26, a potential SARS-CoV-2 receptor, as a biomarker of age and pathology.Bioscience reports · 2020Article
- Nitrate Metabolism Modulates Biosynthesis of Biofilm Components in UropathogenicFrontiers in microbiology · 2020Article
- A Cinematic View of Tissue Microbiology in the Live Infected Host.Microbiology spectrum · 2019Review
- High Resolution Intravital Imaging of the Renal Immune Response to Injury and Infection in Mice.Frontiers in immunology · 2019Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
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Abstract
Bacterial infection of the kidney leads to a rapid cascade of host protective responses, many of which are still poorly understood. We have previously shown that following kidney infection with uropathogenic Escherichia coli (UPEC), vascular coagulation is quickly initiated in local perivascular capillaries that protects the host from progressing from a local infection to systemic sepsis. The signaling mechanisms behind this response have not however been described. In this study, we use a number of in vitro and in vivo techniques, including intravital microscopy, to identify two previously unrecognized components influencing this protective coagulation response. The acylation state of the Lipid A of UPEC lipopolysaccharide (LPS) is shown to alter the kinetics of local coagulation onset in vivo. We also identify epithelial CD147 as a potential host factor influencing infection-mediated coagulation. CD147 is expressed by renal proximal epithelial cells infected with UPEC, contingent to bacterial expression of the α-hemolysin toxin. The epithelial CD147 subsequently can activate tissue factor on endothelial cells, a primary step in the coagulation cascade. This study emphasizes the rapid, multifaceted response of the kidney tissue to bacterial infection and the interplay between host and pathogen during the early hours of renal infection.
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