ArticleCarcinogenesis2019
Dietary N-nitroso compounds and risk of pancreatic cancer: results from a large case-control study.
Article in Carcinogenesis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Modern Approaches to Diagnosis and Evaluation of Survival Prognosis in Patients with Pancreatic Cancer.International journal of molecular sciences · 2026Pooled it
- Association between Dietary Nitrate, Nitrite Intake, and Site-Specific Cancer Risk: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- Dietary exposure to N-nitrosamines and their precursors: an age-stratified assessment.Scientific reports · 2026Article
- Nitrosamines crisis in pharmaceuticals - Insights on toxicological implications, root causes and risk assessment: A systematic review.Journal of pharmaceutical analysis · 2024Review
- Reduction of carcinogens in fermented fish (pla-ra and pla-som) by heating.Veterinary world · 2023Article
- Risk assessment ofEFSA journal. European Food Safety Authority · 2023Article
- Review
- Modifiable and Non-Modifiable Risk Factors for the Development of Non-Hereditary Pancreatic Cancer.Medicina (Kaunas, Lithuania) · 2022Review
- Dietary Intake of Fatty Acids and Risk of Pancreatic Cancer: A Case-Control Study.The Journal of nutrition · 2022Article
- Dietary N-Nitroso Compounds and Risk of Hepatocellular Carcinoma: A USA-Based Study.Hepatology (Baltimore, Md.) · 2021Article
- Estimated Cancer Risks Associated with Nitrosamine Contamination in Commonly Used Medications.International journal of environmental research and public health · 2021Article
- N-Nitrosodimethylamine-Contaminated Valsartan and the Risk of Cancer—A Longitudinal Cohort Study Based on German Health Insurance Data.Deutsches Arzteblatt international · 2021Article
- Carcinogenesis: Failure of resolution of inflammation?Pharmacology & therapeutics · 2021Review
- Intestinal microbiota alterations by dietary exposure to chemicals from food cooking and processing. Application of data science for risk prediction.Computational and structural biotechnology journal · 2021Review
- Article
- New Frontiers about the Role of Human Microbiota in Immunotherapy: The Immune Checkpoint Inhibitors and CAR T-Cell Therapy Era.International journal of molecular sciences · 2020Review
- Nitrates/Nitrites in Food-Risk for Nitrosative Stress and Benefits.Antioxidants (Basel, Switzerland) · 2020Review
- Vitamin C and Vitamin E Mitigate the Risk of Pancreatic Ductal Adenocarcinoma from Meat-Derived Mutagen Exposure in Adults in a Case-Control Study.The Journal of nutrition · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
N-nitroso compounds (NOCs) are among the most potent dietary and pancreatic carcinogens. N-nitrosodiethylamine (NDEA) and N-nitrosodimethylamine (NDMA) are the most prevalent NOCs identified in foods. Using a validated and comprehensive N-nitroso database developed to estimate total NOCs and important individual NOCs from food intake, we investigated dietary exposure to NOCs in relation to pancreatic cancer in a large matched case-control study. Self-administered food frequency questionnaires were collected from 957 pathologically confirmed pancreatic ductal adenocarcinoma cases and 938 frequency-matched controls. For each food item, frequency of intake and portion size in grams was multiplied by the estimated NOC concentration from the N-nitroso database. Multiple unconditional logistic regression models were used to estimate the odds ratios (OR) and 95% confidence intervals (CIs) for pancreatic cancer risk by quartiles of NOCs and major food group contributors to NOCs, with the lowest quartile as referent. Following adjustment for confounders, we observed significant positive associations for NDEA (ORQ4 versus Q1 = 2.28, 95% CI = 1.71-3.04, Ptrend < 0.0001) and NDMA from plant sources (ORQ4 versus Q1 = 1.93, 95% CI = 1.42-2.61, Ptrend < 0.0001) with pancreatic cancer. The major food groups related to NDEA and NDMA intakes in this population were fermented cheese, pizza, grains, seafood and beer. No associations of intake of nitrate or total NOCs were observed; nitrite was inversely associated with pancreatic cancer. Although some of our findings probably reflect reverse causation bias due to lower meat intake in cases with latent disease, biologically plausible findings for pancreatic carcinogens, NDEA and NDMA, warrant further prospective investigation.
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