Trial reportPloS one2018
Investigating speech and language impairments in delirium: A preliminary case-control study.
Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06081569 (Multimodal Deep Learning for the Diagnosis and Assessment of Alzheimer's Disease), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multimodal Deep Learning for the Diagnosis and Assessment of Alzheimer's Disease
Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Cerebral metabolic covariance in delirium: pattern response to symptomatic changes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Bilingual side effect: a case of foreign language syndrome following chlorpromazine-induced neuroleptic malignant syndrome.Annals of general psychiatry · 2025Article
- The Relationship between Delirium and Dementia.Seminars in neurology · 2024Review
- A Clinician's View of Wernicke-Korsakoff Syndrome.Journal of clinical medicine · 2022Review
- Three key areas in progressing delirium practice and knowledge: recognition and relief of distress, new directions in delirium epidemiology and developing better research assessments.Age and ageing · 2022Article
- Identifying Delirium in Persons With Moderate or Severe Dementia: Review of Challenges and an Illustrative Approach.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Review
- Delirium on stroke units: a prospective, multicentric quality-improvement project.Journal of neurology · 2022Article
- Lost in another language: a case report.Journal of medical case reports · 2022Article
- Correlating natural language processing and automated speech analysis with clinician assessment to quantify speech-language changes in mild cognitive impairment and Alzheimer's dementia.Alzheimer's research & therapy · 2021Article
- The role of speech and language therapists in the intensive care unit.Journal of the Intensive Care Society · 2020Article
- Use of analgesics in acute stroke patients with inability to self-report pain: a retrospective cohort study.BMC neurology · 2020Article
- Delirium Screening in Aphasic Patients With the Intensive Care Delirium Screening Checklist (ICDSC): A Prospective Cohort Study.Frontiers in neurology · 2019Article
- Characterizing and detecting delirium with clinical and computational measures of speech and language disturbance.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
introductionLanguage impairment is recognized as as part of the delirium syndrome, yet there is little neuropsychological research on the nature of this dysfunction. Here we hypothesized that patients with delirium show impairments in language formation, coherence and comprehension.
methodsThis was a case-control study in 45 hospitalized patients (aged 65-97 years) with delirium, dementia without delirium, or no cognitive impairment (N = 15 per group). DSM-5 criteria were used for delirium. Speech was elicited during (1) structured conversational questioning, and (2) the "Cookie Theft" picture description task. Language comprehension was assessed through standardized verbal and written commands. Interviews were audio-recorded and transcribed.
resultsDelirium and dementia groups scored lower on the conversational assessment than the control group (p<0.01, moderate effect sizes (r) of 0.48 and 0.51, resp.). In the Cookie Theft task, the average length of utterances (i.e. unit of speech), indicating language productivity and fluency, distinguished patients with delirium from those with dementia (p<0.01, r = 0.50) and no cognitive impairment (p<0.01, r = 0.55). Patients with delirium performed worse on written comprehension tests compared to cognitively unimpaired patients (p<0.01, r = 0.63), but not compared to the dementia group.
conclusionsProduction of spontaneous speech, word quantity, speech content and verbal and written language comprehension are impaired in delirious patients compared to cognitively unimpaired patients. Additionally, patients with delirium produced significantly less fluent speech than those with dementia. These findings have implications for how speech and language are evaluated in delirium assessments, and also for communication with patients with delirium. A study limitation was that the delirium group included patients with co-morbid dementia, which precludes drawing conclusions about the specific language profile of delirium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.