ArticleJournal of Alzheimer's disease : JAD2019
Systematic Multi-Domain Alzheimer's Risk Reduction Trial (SMARRT): Study Protocol.
Article in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Canadian Stroke Best Practice Recommendations: Vascular cognitive impairment, 7th edition practice guidelines update, 2024.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Guideline
- Leisure-Related Social Work Interventions for Patients with Cognitive Impairment: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023Pooled it
- Multi-Domain Interventions for Dementia Prevention - A Systematic Review.The journal of nutrition, health & aging · 2023Pooled it
- How are people with mild cognitive impairment or subjective memory complaints managed in primary care? A systematic review.Family practice · 2021Pooled it
- Multidomain intervention for dementia prevention: a scoping review.Frontiers in neurologyPooled it
- The Impact of Pandemic-Related Restrictions on Dementia Risk Factors in Older Adults.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2024Trial
- Dietary Patterns and Cognitive Decline in Older Adults: Findings from the Western Australia Memory Study.Nutrients · 2026Article
- The forgotten population: Early-onset Alzheimer's in people with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Implementing brain health strategies in primary care: methods and baseline findings from the BHAM registry.Archives of public health = Archives belges de sante publique · 2025Article
- Adherence and intensity in multimodal lifestyle-based interventions for cognitive decline prevention: state-of-the-art and future directions.Alzheimer's research & therapy · 2025Review
- Dementia risk reduction in the African context: Multi-national implementation of multimodal strategies to promote healthy brain aging in Africa (the Africa-FINGERS project).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The Systematic Multi-domain Alzheimer's Risk Reduction Trial (SMARRT) intervention: A personalized approach to dementia risk reduction.Journal of Alzheimer's disease : JAD · 2024Article
- Intervention Development for Tailored Education for Aging and Cognitive Health (TEACH) for Dementia Prevention in Midlife Adults: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2024Article
- Study design and methods: U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Observational studies in Alzheimer disease: bridging preclinical studies and clinical trials.Nature reviews. Neurology · 2022Review
- Physical inactivity in older adults with cognitive impairment without dementia: room for improvement.Aging clinical and experimental research · 2022Article
- Adherence to Life's Simple 7 and Cognitive Function Among Older Adults: The National Health and Nutrition Examination Survey 2011 to 2014.Journal of the American Heart Association · 2022Article
- Alzheimer's Disease Prevention Health Coaching.The journal of prevention of Alzheimer's disease · 2022Article
- Glucose-Dementia Association Is Consistent Over Blood Pressure/Antihypertensive Groups.Journal of Alzheimer's disease : JAD · 2021Article
- A systems-biology clinical trial of a personalized multimodal lifestyle intervention for early Alzheimer's disease.Alzheimer's & dementia (New York, N. Y.) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
This article describes the protocol for the Systematic Multi-domain Alzheimer's Risk Reduction Trial (SMARRT), a single-blind randomized pilot trial to test a personalized, pragmatic, multi-domain Alzheimer's disease (AD) risk reduction intervention in a US integrated healthcare delivery system. Study participants will be 200 higher-risk older adults (age 70-89 years with subjective cognitive complaints, low normal performance on cognitive screen, and ≥ two modifiable risk factors targeted by our intervention) who will be recruited from selected primary care clinics of Kaiser Permanente Washington, oversampling people with non-white race or Hispanic ethnicity. Study participants will be randomly assigned to a two-year Alzheimer's risk reduction intervention (SMARRT) or a Health Education (HE) control. Randomization will be stratified by clinic, race/ethnicity (non-Hispanic white versus non-white or Hispanic), and age (70-79, 80-89). Participants randomized to the SMARRT group will work with a behavioral coach and nurse to develop a personalized plan related to their risk factors (poorly controlled hypertension, diabetes with evidence of hyper or hypoglycemia, depressive symptoms, poor sleep quality, contraindicated medications, physical inactivity, low cognitive stimulation, social isolation, poor diet, smoking). Participants in the HE control group will be mailed general health education information about these risk factors for AD. The primary outcome is two-year cognitive change on a cognitive test composite score. Secondary outcomes include: 1) improvement in targeted risk factors, 2) individual cognitive domain composite scores, 3) physical performance, 4) functional ability, 5) quality of life, and 6) incidence of mild cognitive impairment, AD, and dementia. Primary and secondary outcomes will be assessed in both groups at baseline and 6, 12, 18, and 24 months.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.