Evidence map›Paper›PMID 30475656›Full record

ReviewPhysiological reviews2019

Wound Healing: A Cellular Perspective.

Melanie Rodrigues, Nina Kosaric, Clark A Bonham, Geoffrey C Gurtner

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Physiological reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06298110 (The Effect of PRP on Wound Healing in High Risk Patients Undergoing Abdominal Hysterectomy), which is not on this map. Cited by 1,348 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,348citing papers in PubMed, 5 pooled it
70.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06298110 phase2 / phase3unknown statusnot on this mapstarted 2024, after this paper: background citation

The Effect of PRP on Wound Healing in High Risk Patients Undergoing Abdominal Hysterectomy

TypeinterventionalSponsorHelwan UniversityRan2024 to 2024Enrolled80ConditionsWound Heal, Abdominal Wound, PRPArmsPlatelets Rich plasma of the same patient
3 · Its place in the literature

Who cites it

1,348 citing papers in PubMed, 5 syntheses or guidelines pooled it, 2,764 citations in OpenAlex.

  1. Toxins turned into medicines: A systematic review of peptide animal-derived venom in wound treatments.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026
    Pooled it
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  9. Therapeutic potential ofPharmaceutical biology · 2026
    Review
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  16. HarnessingFood science & nutrition · 2026
    Review
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1,288 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Melanie RodriguesDepartment of Surgery, Stanford University School of Medicine , Stanford, California.
Nina KosaricDepartment of Surgery, Stanford University School of Medicine , Stanford, California.
Clark A BonhamDepartment of Surgery, Stanford University School of Medicine , Stanford, California.
Geoffrey C GurtnerDepartment of Surgery, Stanford University School of Medicine , Stanford, California.
Stanford University · US

Funding

Reversal of Progenitor Cell Deficits in DiabetesR01DK074095 · NIDDK · UNIVERSITY OF ARIZONA · PI GURTNER, GEOFFREY C · 2005 to 2025
$6.4M
Targeting HIF-1 alpha Dysfunction in Complications of AgingR01AG025016 · NIA · STANFORD UNIVERSITY · PI GURTNER, GEOFFREY C · 2004 to 2015
$3.5M
NIA NIH HHS R01 AG025016NIDDK NIH HHS R01 DK074095
6 · The paper itself

Abstract

Wound healing is one of the most complex processes in the human body. It involves the spatial and temporal synchronization of a variety of cell types with distinct roles in the phases of hemostasis, inflammation, growth, re-epithelialization, and remodeling. With the evolution of single cell technologies, it has been possible to uncover phenotypic and functional heterogeneity within several of these cell types. There have also been discoveries of rare, stem cell subsets within the skin, which are unipotent in the uninjured state, but become multipotent following skin injury. Unraveling the roles of each of these cell types and their interactions with each other is important in understanding the mechanisms of normal wound closure. Changes in the microenvironment including alterations in mechanical forces, oxygen levels, chemokines, extracellular matrix and growth factor synthesis directly impact cellular recruitment and activation, leading to impaired states of wound healing. Single cell technologies can be used to decipher these cellular alterations in diseased states such as in chronic wounds and hypertrophic scarring so that effective therapeutic solutions for healing wounds can be developed.

Indexed as

AnimalsBlood PlateletsExtracellular MatrixHemostasisHumansNeovascularization, PhysiologicSkinWound Healing

Identifiers

PMID30475656
PMCPMC6442927
OpenAlexW2902282736

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.