Evidence map›Paper›PMID 30475260›Full record

SynthesisThe Clinical journal of pain2019

Dexmedetomidine as an Adjuvant to Local Anesthetics in Transversus Abdominis Plane Block: A Systematic Review and Meta-analysis.

Qianchuang Sun, Shuyan Liu, Huiying Wu, He Ma, Wei Liu, Meidan Fang, Kexiang Liu, Zhenxiang Pan

2 registry-linked trialsOpen access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Clinical journal of pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 5 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05840406 nacompletednot on this mapstarted 2024, after this paper: background citation

Effect of a Transversus Abdominis Plane Block on Operative Wound Healing, Stress, and Immune Response After a Cesarean Delivery

TypeinterventionalSponsorUniversity Hospital Sestre MilosrdniceRan2024 to 2025Enrolled105ConditionsPostoperative Pain, Cesarean Section, Wound HealArmsPostoperative pain management with acetaminophen, Bilateral TAP Block with levobupivacaine, Bilateral TAP Block with levobupivacaine and dexmedetomidine, Postoperative pain management with tramadol, Postoperative pain management with ketoprofen
NCT06187922 phase4unknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of Perioperative Oral Pregabalin in Total Knee Replacement for Postoperative Pain

TypeinterventionalSponsorBahrain Defence Force HospitalRan2023 to 2025Enrolled120ConditionsPostoperative PainArmsPregabalin 75mg, adductor canal block
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 5 syntheses or guidelines pooled it, 69 citations in OpenAlex.

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  15. Mechanism, Dose, and Administration of Dexmedetomidine in Managing Visceral Pain Associated With Surgery: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Qianchuang SunDepartment of Anesthesiology.
Shuyan LiuOphthalmology.
Huiying WuUltrasonic Diagnosis.
He MaDepartment of Anesthesiology.
Wei LiuDepartment of Anesthesiology.
Meidan FangDepartment of Anesthesiology.
Kexiang LiuCardiovascular Surgery, The Second Hospital of Jilin University, Changchun, China.
Zhenxiang PanDepartment of Anesthesiology.
Ophthalmology Associates (United States) · USSecond Affiliated Hospital of Jilin University · CNUltrasonic Technologies (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe objective of this meta-analysis was to evaluate the analgesic effects of dexmedetomidine (DEX) in transversus abdominis plane (TAP) blocks for abdominal surgery.

methodsElectronic databases, including PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), Wan Fang, and the Cochrane Library, were conducted to collect the randomized controlled trials (RCTs) from inception to March 2018. RCTs investigating the impact of adding DEX to local anesthetics for TAP blocks were included in this analysis. Pain scores (at rest and movement), opioid consumption, the duration of the TAP block and the common adverse effects were analyzed.

resultsTwenty published trials including 1212 patients met the inclusion criteria. The addition of DEX significantly reduced pain scores 8 hours postoperatively at rest (WMD, -0.78; 95% CI, -1.27 to -0.30; P=0.001), 4 hours postoperatively on movement (WMD, -1.13; 95% CI, -1.65 to -0.60; P<0.001), and opioid consumption (WMD, -13.71; 95% CI, -17.83 to -9.60; P<0.001) when compared with control group. Furthermore, perineural DEX significantly prolonged the duration of the TAP block (WMD, 3.33; 95% CI, 2.85 to 3.82; P<0.001). It did not affect the incidence of postoperative nausea and vomiting, hypotension, bradycardia, somnolence, or pruritus.

conclusionsDEX is a potential anesthetic adjuvant that can facilitate better postoperative analgesia, reduce postoperative analgesic requirements, and prolong the local anesthetic effect when administered in TAP blocks.

Indexed as

Abdominal MusclesAdjuvants, AnesthesiaAnesthetics, LocalDexmedetomidineHumansNerve BlockAdjuvants, AnesthesiaAnesthetics, LocalDexmedetomidine

Identifiers

PMID30475260
PMCPMC6410974
OpenAlexW3142130703

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.