ArticleeLife2018
Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition.
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Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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74citing papers in PubMed
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Who cites it
74 citing papers in PubMed, 77 citations in OpenAlex.
- Altered neuronal start codon stringency favors cap-independent repeat-associated non-AUG translation.Nucleic acids research · 2026Article
- Translation Initiation Fidelity Defective Mutations in eIF5 and eIF2β Show Distinct Sensitivity to the Sequence Context for Recognition of the UUG Start Codon.Biochemical genetics · 2026Article
- Altered neuronal start codon stringency favors cap-independent repeat-associated non-AUG translation.bioRxiv : the preprint server for biology · 2026Article
- Review
- Translation initiation by the Kozak mRNA sequence is based on a conformational readout on the ribosome.Nature communications · 2026Article
- Interplay of the ribosome A and CAR sites.NAR genomics and bioinformatics · 2026Article
- Toward a unifying mechanistic model of eukaryotic translation initiation through integrative single-molecule, structural, and computational insights.Current opinion in structural biology · 2026Review
- The eIF5-mimic protein 5MP1: a regulator of translation stringency and a multifaceted oncogene.Journal of biochemistry · 2026Review
- Novel insights into the assembly of the yeast translation initiation multifactor complex: The critical role of eIF5.Protein science : a publication of the Protein Society · 2026Article
- Translational control of Toxoplasma gondii differentiation.Bioscience reports · 2026Review
- Structural basis for non-AUG translation regulation by 5MPs.bioRxiv : the preprint server for biology · 2025Article
- eIF3: a critical player in mRNA recruitment to the ribosome with emerging roles across translation.Biochemical Society transactions · 2025Review
- Eukaryotic translation initiation factor 4F: functional properties and physiological role.Nucleic acids research · 2025Review
- eIF1 and eIF5 dynamically control translation start site fidelity.Nature structural & molecular biology · 2025Article
- Characterizing the Human Fetal Perimeiotic 45,X Ovary at Single-Cell Resolution.Journal of the Endocrine Society · 2025Article
- Exploring the interaction dynamics of eukaryotic translation initiation factor 2.Biochemical Society transactions · 2025Review
- A structural element within the 5'UTR of β-catenin mRNA modulates its translation under hypoxia.Nucleic acids research · 2025Article
- Distinct uS11/Rps14 interactions with the translation preinitiation complex differentially alter the accuracy of start codon recognition.Nucleic acids research · 2025Article
- Structures of Saccharolobus solfataricus initiation complexes with leaderless mRNAs highlight archaeal features and eukaryotic proximity.Nature communications · 2025Article
- Structural basis for translational control by the human 48S initiation complex.Nature structural & molecular biology · 2025Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 4 countries.
Jose Luis Llácer *MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0001-5304-1795
Tanweer Hussain *Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India.
Adesh K Saini *Shoolini University of Biotechnology and Management Sciences, Himachal Pradesh, India.ORCID http://orcid.org/0000-0002-5445-5786
Jagpreet Singh Nanda *Laboratory on the Mechanism and Regulation of Protein Synthesis, Eunice K Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.ORCID https://orcid.org/0000-0001-5387-8683
Sukhvir KaurShoolini University of Biotechnology and Management Sciences, Himachal Pradesh, India.
Yuliya GordiyenkoMRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
Rakesh KumarShoolini University of Biotechnology and Management Sciences, Himachal Pradesh, India.
Alan G HinnebuschLaboratory of Gene Regulation and Development, Eunice K Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Jon R LorschLaboratory on the Mechanism and Regulation of Protein Synthesis, Eunice K Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.ORCID http://orcid.org/0000-0002-4521-4999
V RamakrishnanMRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USIndian Institute of Science Bangalore · INInstituto de Biomedicina de Valencia · ESShoolini University · IN
Funding
Translational & Transcriptional Control Of Gene Expression By Nutrients In YeastZIAHD001004 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI HINNEBUSCH, ALAN G · 2009 to 2025
$34.4MElucidating the Molecular Mechanics of Eukaryotic Translation Initiation and Its ControlZIAHD008940 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI LORSCH, JON · 2014 to 2025
$9.5MKINETIC DISSECTION OF EUKARYOTIC TRANSLATION INITIATIONR01GM062128 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 2000 to 2013
$4.6MMedical Research Council MC_U105184332NIGMS NIH HHS R01 GM062128NIH HHS GM62128Wellcome TrustWellcome Trust WT096570
Abstract
In eukaryotic translation initiation, AUG recognition of the mRNA requires accommodation of Met-tRNA
Indexed as
Protein BiosynthesisBinding SitesCodon, InitiatorCryoelectron MicroscopyEukaryotic Initiation Factor-1Eukaryotic Initiation Factor-2Eukaryotic Translation Initiation Factor 5AGene Expression Regulation, FungalPeptide Initiation FactorsRibosomesRibosome Subunits, Small, EukaryoticRNA-Binding ProteinsSaccharomyces cerevisiaeCodon, InitiatorEukaryotic Initiation Factor-1Eukaryotic Initiation Factor-2eukaryotic peptide initiation factor-1AEukaryotic Translation Initiation Factor 5APeptide Initiation FactorsRNA-Binding ProteinseIF5Kluyveromyces lactismolecular biophysicsribosomeS. cerevisiaestructural biologyTranslation initiation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.