Evidence map›Paper›PMID 30475208›Full record

ArticleeLife2018

Joseph M Chambers, Shahram Jevin Poureetezadi, Amanda Addiego, Manuela Lahne, Rebecca A Wingert

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Principles of Zebrafish Nephron Segment Development.Journal of developmental biology · 2023
    Review
  8. Review
  9. Article
  10. Review
  11. Biomedicines · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Prostaglandin signaling regulates renal multiciliated cell specification and maturation.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Joseph M ChambersDepartment of Biological Sciences, University of Notre Dame, Indiana, United States.
Shahram Jevin PoureetezadiDepartment of Biological Sciences, University of Notre Dame, Indiana, United States.
Amanda AddiegoDepartment of Biological Sciences, University of Notre Dame, Indiana, United States.
Manuela LahneDepartment of Biological Sciences, University of Notre Dame, Indiana, United States.
Rebecca A WingertDepartment of Biological Sciences, University of Notre Dame, Indiana, United States.ORCID http://orcid.org/0000-0003-3133-7549
University of Notre Dame · US

Funding

The Laminin Receptors in Kidney FibrosisR01DK069921 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ROY ZENT · 2005 to 2026
$9.5M
Generation of novel models of kidney defects using the zebrafishR01DK100237 · NIDDK · UNIVERSITY OF NOTRE DAME · PI WINGERT, REBECCA ANN · 2013 to 2017
$1.8M
NIDDK NIH HHS R01 DK069921NIDDK NIH HHS R01 DK100237NIH HHS R01DK100237
6 · The paper itself

Abstract

Nephron segmentation involves a concert of genetic and molecular signals that are not fully understood. Through a chemical screen, we discovered that alteration of peroxisome proliferator-activated receptor (PPAR) signaling disrupts nephron segmentation in the zebrafish embryonic kidney (Poureetezadi et al., 2016). Here, we show that the PPAR co-activator

Indexed as

Body PatterningAmino Acid SequenceAnimalsBezafibrateEmbryo, NonmammalianGene Expression Regulation, DevelopmentalGenetic TestingMorpholinosNephronsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhenotypePronephrosRNA, MessengerSignal TransductionSmall Molecule LibrariesTranscription FactorsBezafibrateMorpholinosPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphappargc1a protein, zebrafishRNA, MessengerSmall Molecule LibrariesTranscription FactorsZebrafish Proteinsdevelopmental biologykidneynephronppargc1apronephrossegmentationsim1azebrafish

Identifiers

PMID30475208
PMCPMC6279350
OpenAlexW2902678361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.