ArticleNeuropsychology2019
Contributions of olfactory and neuropsychological assessment to the diagnosis of first-episode schizophrenia.
Article in Neuropsychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Association of Odor Identification Ability With Amyloid-β and Tau Burden: A Systematic Review and Meta-Analysis.Frontiers in neuroscience · 2020Pooled it
- Inflammation-related pathology in the olfactory epithelium: its impact on the olfactory system in psychotic disorders.Molecular psychiatry · 2024Article
- Frequency modulation increases the specificity of time-resolved connectivity: A resting-state fMRI study.Network neuroscience (Cambridge, Mass.) · 2024Article
- Differences in olfactory dysfunction and its relationship with cognitive function in schizophrenia patients with and without auditory verbal hallucinations.European archives of psychiatry and clinical neuroscience · 2023Article
- Unraveling the Link between Olfactory Deficits and Neuropsychiatric Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Olfactory Dysfunction in Mental Illness.Current allergy and asthma reports · 2023Review
- Brain regions associated with olfactory dysfunction in first episode psychosis patients.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2023Article
- Olfactory Dysfunction in Schizophrenia: Evaluating Olfactory Abilities Across Species.Current topics in behavioral neurosciences · 2023Review
- Deficits in odor discrimination versus odor identification in patients with schizophrenia and negative correlations with GABAergic and DNA methyltransferase mRNAs in lymphocytes.Frontiers in psychiatry · 2023Article
- A comparative neuroimaging perspective of olfaction and higher-order olfactory processing: on health and disease.Seminars in cell & developmental biology · 2022Review
- Olfactory impairment in psychiatric disorders: Does nasal inflammation impact disease psychophysiology?Translational psychiatry · 2022Review
- Sex-specific involvement of the Notch-JAG pathway in social recognition.Translational psychiatry · 2022Article
- A multimodal study of a first episode psychosis cohort: potential markers of antipsychotic treatment resistance.Molecular psychiatry · 2022Article
- Causal impact of local inflammation in the nasal cavity on higher brain function and cognition.Neuroscience research · 2021Article
- Multimodal MRI assessment for first episode psychosis: A major change in the thalamus and an efficient stratification of a subgroup.Human brain mapping · 2021Article
- Relationship between neuropsychological behavior and brain white matter in first-episode psychosis.Schizophrenia research · 2019Article
- Olfactory Epithelium Infection by SARS-CoV-2: Possible Neuroinflammatory Consequences of COVID-19.Complex psychiatryReview
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Authors and funding
7 authors.
Funding
Abstract
objectiveFirst-episode schizophrenia and schizoaffective patients (SZ+) show olfactory impairments, but how these relate to cognitive dysfunction remains unclear. We examined the relationship between cognitive and olfactory dysfunction in SZ+ and the clinical utility of these measures in the assessment of SZ+ patients.
methodFirst-episode SZ+ patients (n = 63) and controls (n = 63) were administered tests of odor identification and discrimination in addition to measures of manual dexterity, processing speed, attention and working memory, executive functioning, ideational fluency, and memory. We analyzed the relationships between olfactory and cognitive variables and conducted stepwise multiple regressions to identify which cognitive indices best predicted olfactory performance within the SZ+ group. Linear discriminant analysis was used to identify which measures best distinguished cases from controls.
resultsAmong patients, odor discrimination correlated with perseverative errors and odor identification correlated with bilateral manual dexterity. Odor discrimination performance was best predicted by perseverative errors and letter fluency, whereas odor identification ability was best predicted by manual dexterity. Stepwise linear discriminant analysis revealed that manual dexterity, letter-guided word fluency, and odor discrimination best distinguished SZ+ from healthy adults.
conclusionsThese findings indicate that manual dexterity, letter-guided word fluency, and odor discrimination may provide incremental information that strengthens a diagnosis of SZ+. Although odor discrimination tasks have received limited attention in schizophrenia studies, the extant data along with the present results indicate that odor discrimination tasks may have utility over odor identification measures as a neurodevelopmental risk marker. Additional studies examining odor discrimination as a predictor of SZ spectrum illness are warranted. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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