Evidence map›Paper›PMID 30474936›Full record

Observational studyESC heart failure2019

Association between lung ultrasound findings and invasive exercise haemodynamics in patients with undifferentiated dyspnoea.

Elke Platz, Allison Merz, Montane Silverman, Eldrin Lewis, John D Groarke, Aaron Waxman, David Systrom

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in ESC heart failure, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Recommendations for Lung Ultrasound in Internal Medicine.Diagnostics (Basel, Switzerland) · 2020
    Guideline
  3. Review
  4. Article
  5. Review
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elke PlatzDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Allison MerzHarvard Medical School, Boston, MA, USA.
Montane SilvermanF. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Eldrin LewisHarvard Medical School, Boston, MA, USA.
John D GroarkeHarvard Medical School, Boston, MA, USA.
Aaron WaxmanHarvard Medical School, Boston, MA, USA.
David SystromHarvard Medical School, Boston, MA, USA.

Funding

Utility of Lung Ultrasound in Assessing Pulmonary Congestion in Heart FailureK23HL123533 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI PLATZ, ELKE · 2015 to 2019
$881k
NHLBI NIH HHS K23 HL123533NHLBI NIH HHS K23HL123533
6 · The paper itself

Abstract

aimsDyspnoea is common in heart failure (HF) but non-specific. Lung ultrasound (LUS) could represent a non-invasive tool to detect subclinical pulmonary congestion in patients with undifferentiated dyspnoea. METHODS AND

resultsWe assessed the feasibility of an abbreviated LUS protocol (eight and two zones) in a prospective pilot study of 25 ambulatory patients with undifferentiated dyspnoea undergoing clinically indicated invasive cardiopulmonary exercise testing (iCPET) at rest (LUS 1) and after peak exercise (LUS 2). We also related LUS findings (B-lines) to invasive haemodynamics stratified by supine pulmonary capillary wedge pressure (PCWP) (Congestion, >15 mmHg; Control, ≤15 mmHg). All enrolled patients (median age 68, 60% women, 32% prior HF, median ejection fraction 59%) had interpretable LUS 1 images in eight zones, and 20 (80%) had adequate LUS 2 images. LUS images were adequate in two posterior zones in 24 patients (96%) for LUS 1 and 18 (72%) for LUS 2. Although B-line number was numerically higher in the Congestion group at rest and after peak exercise, this difference did not reach statistical significance. In the entire cohort, there was an association between B-lines and rest systolic pulmonary artery pressure (r = 0.46, P = 0.02) and PCWP (r = 0.54, P = 0.005). There was an inverse relationship between B-lines and peak VO

conclusionsAmong ambulatory patients with undifferentiated dyspnoea, an abbreviated LUS protocol before and after iCPET is feasible in the majority of patients. B-line number at rest was associated with invasively measured markers of haemodynamic congestion and was inversely related with peak VO

Indexed as

AdultAgedAged, 80 and overDyspneaExerciseFeasibility StudiesFemaleHemodynamicsHumansLungMaleMiddle AgedPilot ProjectsPrognosisProspective StudiesROC CurveCongestionDyspnoeaInvasive haemodynamicsLung ultrasound

Identifiers

PMID30474936
PMCPMC6352886

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.