ArticleAddiction (Abingdon, England)2019
Exploring the relationship between polygenic risk for cannabis use, peer cannabis use and the longitudinal course of cannabis involvement.
Article in Addiction (Abingdon, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Can Psychiatric Genetics Advance Without Incorporating a Life Course Perspective?Biological psychiatry · 2026Review
- The Promise of Genetics in Alcohol Use Disorders and the Problems of Phenotype, Polygenetic Architecture, Ancestry, and Comorbidity.The American journal of psychiatry · 2025Article
- Intergenerational Transmission of Cannabis Use: Testing Genetic Risk and the Mitigating Influences of Parent Positive Behavior Support in Early Childhood.Research on child and adolescent psychopathology · 2025Article
- Predicting Genetic Risk for Impulsivity and Substance Use in Adolescence.medRxiv : the preprint server for health sciences · 2025Article
- COVID-19 pandemic stressors are associated with reported increases in frequency of drunkenness among individuals with a history of alcohol use disorder.Translational psychiatry · 2023Article
- The collaborative study on the genetics of alcoholism: Genetics.Genes, brain, and behavior · 2023Review
- The Collaborative Study on the Genetics of Alcoholism: Overview.Genes, brain, and behavior · 2023Review
- Adverse childhood experiences and adolescent cannabis use trajectories: findings from a longitudinal UK birth cohort.The Lancet. Public health · 2023Article
- Genetics of cannabis use in opioid use disorder: A genome-wide association and polygenic risk score study.PloS one · 2023Article
- The genetic aetiology of cannabis use: from twin models to genome-wide association studies and beyond.Translational psychiatry · 2022Review
- Variations of cannabis-related adverse mental health and addiction outcomes across adolescence and adulthood: A scoping review.Frontiers in psychiatry · 2022Article
- The Associations of Polygenic Scores for Risky Behaviors and Parenting Behaviors with Adolescent Externalizing Problems.Behavior genetics · 2022Article
- Effects of genetic risk for alcohol dependence and onset of regular drinking on the progression to alcohol dependence: A polygenic risk score approach.Drug and alcohol dependence · 2022Article
- Prefrontal fNIRS-based clinical data analysis of brain functions in individuals abusing different types of drugs.Journal of biomedical semantics · 2021Article
- Genetics of substance use disorders in the era of big data.Nature reviews. Genetics · 2021Review
- The intermediary role of adolescent temperamental and behavioral traits on the prospective associations between polygenic risk and cannabis use among young adults of European Ancestry.Addiction (Abingdon, England) · 2021Article
- Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
BACKGROUND AND
aimsFew studies have explored how polygenic propensity to cannabis use unfolds across development, and no studies have yet examined this question in the context of environmental contributions such as peer cannabis use. Outlining the factors that contribute to progression from cannabis initiation to problem use over time may ultimately provide insights into mechanisms for targeted interventions. We sought to examine the relationships between polygenic liability for cannabis use, cannabis use trajectories from ages 12-30 years and perceived peer cannabis use at ages 12-17 years.
designMixed-effect logistic and linear regressions were used to examine associations between polygenic risk scores, cannabis use trajectory membership and perceived peer cannabis use.
settingUnited States.
participantsFrom the Collaborative Study on the Genetics of Alcoholism (COGA) study, a cohort of 1167 individuals aged 12-26 years at their baseline (i.e. first) interview. MEASUREMENTS: Key measurements included life-time cannabis use (yes/no), frequency of past 12-month cannabis use, maximum life-time frequency of cannabis use, cannabis use disorder (using DSM-5 criteria) and perceived peer cannabis use. Polygenic risk scores (PRS) were created using summary statistics from a large (n = 162 082) genome-wide association study (GWAS) of cannabis use.
findingsThree trajectories reflecting no/low (n = 844), moderate (n = 137) and high (n = 186) use were identified. PRS were significantly associated with trajectory membership [P = 0.002-0.006, maximum conditional R
conclusionsGenetic propensity to cannabis use derived from heterogeneous samples appears to correlate with longitudinal increases in cannabis use frequency in young adults.
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Registered trials
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