Evidence map›Paper›PMID 30474824›Full record

ArticleEndocrine2019

Validation and comparison of three newly-released Thyroid Imaging Reporting and Data Systems for cancer risk determination.

Ting Xu, Ya Wu, Run-Xin Wu, Yu-Zhi Zhang, Jing-Yu Gu, Xin-Hua Ye, Wei Tang, Shu-Hang Xu, Chao Liu, Xiao-Hong Wu

Abstract readComparative StudyValidation Study
PubMed Publisher
In one paragraph

Article in Endocrine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 9 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 9 syntheses or guidelines pooled it, 117 citations in OpenAlex.

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  18. Comparative evaluation of shear wave elastography elasticity values in thyroid nodules with cytology results and TI-RADS scoring in differentiation of benign-malignant nodules.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ting XuDepartment of Endocrinology, Jiangsu Province Official Hospital, Nanjing, China.
Ya WuDepartment of Endocrinology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Run-Xin WuNanjing Foreign Languages School, Nanjing, China.
Yu-Zhi ZhangDepartment of Ultrasound, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China.
Jing-Yu GuDepartment of Endocrinology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Xin-Hua YeDepartment of Ultrasound, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Wei TangDepartment of Endocrinology, Jiangsu Province Official Hospital, Nanjing, China.
Shu-Hang XuDepartment of Endocrinology, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China.
Chao LiuDepartment of Endocrinology, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China.
Xiao-Hong WuDepartment of Endocrinology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China. drxhwu@njmu.edu.cn.ORCID 0000-0001-5984-3342
Jiangsu Province Hospital · CNNanjing Medical University · CNNanjing Foreign Language School · CN

Funding

Jiangsu Province key medical personnel project RC2011068National Natural Science Foundation of China 81261120566
6 · The paper itself

Abstract

purposeTo validate and compare diagnostic value of three newly-released Thyroid Imaging Reporting and Data Systems (TIRADS) for cancer risk determination.

methodsTotal 2031 patients with 2465 thyroid nodules were recruited for this study. Ultrasound (US) images were categorized based on three TIRADS editions established by Korean Society of Thyroid Radiology (KSThR), European Thyroid Association (ETA) and American College of Radiology (ACR). ROC curves were established to compare diagnostic value.

resultsTotal 1460 benign and 1005 malignant nodules were enrolled. The malignancy rates of each category in KSThR-TIRADS were 2.8%, 5.1%, 33.7% and 79.6%, respectively. For European-TIRADS, 0, 3.1, 22.8, and 73.5% of nodules categorized as 2 to 5 were malignant. Distribution of carcinomas among ACR-TIRADS categories was 0%, 2.3%, 7.5%, 40.1% and 81.4%, respectively. In terms of diagnostic value, KSThR-TIRADS had highest AUC (0.855) and specificity (87.4%), while lowest (71.4%) sensitivity. ACR-TIRADS showed best sensitivity (96.6%) with lowest specificity (52.9%) and the AUC (0.846) was slightly lower than KSThR-TIRADS. Total 56.1, 45.4, and 37.4% fine-needle aspiration biopsy (FNAB) were recommended by KSThR, ETA and ACR, revealing 42.8%, 44.5% and 53.6% malignant lesions, respectively. The rate of unnecessary FNAB was lowest with the ACR (17.3%), followed by ETA (25.2%) and KSThR (32.1%).

conclusionAll these US models showed great value in predicting thyroid malignancy. Among them, KSThR-TIRADS showed the most effective diagnostic performance in specificity, while ACR-TIRADS yielded best sensitivity. As for FNAB criteria, ACR-TIRADS showed the lowest rate of unnecessary FNAB and highest rate of malignancy in FNAB.

Indexed as

AdultData SystemsFemaleHumansMaleMiddle AgedPrognosisRisk AssessmentROC CurveThyroid GlandThyroid NeoplasmsThyroid NoduleUltrasonographyDiagnostic valueMalignancyThyroid noduleUltrasound

Identifiers

PMID30474824
OpenAlexW2901702315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.