ArticleVirchows Archiv : an international journal of pathology2019
Validation of the pathological prognostic staging system proposed in the revised eighth edition of the AJCC staging manual in different molecular subtypes of breast cancer.
Article in Virchows Archiv : an international journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Validation of the AJCC prognostic stage for HER2-positive breast cancer in the ShortHER trial.BMC medicine · 2019Trial
- Postmastectomy radiotherapy indications using pathological prognostic staging in node-positive breast cancer.Gland surgery · 2025Article
- Single-cell analysis reveals tumour size as a key driver of immune cell profile alterations in primary breast tumours and corresponding lymph nodes.BJC reports · 2025Article
- Impact of immunohistochemistry staining conditions on the incidence of human epidermal growth factor receptor 2 (HER2)-low breast cancer.Virchows Archiv : an international journal of pathology · 2024Article
- Are All Prognostic Stage IB Breast Cancers Equivalent?Cancers · 2024Article
- Validation of the AJCC 8th Edition Breast Cancer Prognostic Staging System in Legacy Alliance Trials (AFT-01).Annals of surgical oncology · 2024Article
- Associations amongst genes, molecules, cells, and organs in breast cancer metastasis.Clinical & experimental metastasis · 2024Review
- Stage-Specific Survival in Breast Cancer in Chinese and White Women: Comparative Data Analysis.JMIR public health and surveillance · 2022Article
- Article
- PET/CT-based radiomics analysis may help to predict neoadjuvant chemotherapy outcomes in breast cancer.Frontiers in oncology · 2022Article
- Triple-negative breast cancer outcomes: Does AJCC 8th staging improve chemotherapy decision-making.Breast (Edinburgh, Scotland) · 2021Article
- Gene expression comparison between primary estrogen receptor-positive and triple-negative breast cancer with paired axillary lymph node metastasis.The breast journal · 2021Article
- Prognostic value of using glucosylceramide synthase and cytochrome P450 family 1 subfamily A1 expression levels for patients with triple-negative breast cancer following neoadjuvant chemotherapy.Experimental and therapeutic medicine · 2021Article
- The comparison of the anatomic stage and pathological prognostic stage according to the AJCC 8th edition for the prognosis in Japanese breast cancer patients: data from a single institution.Breast cancer (Tokyo, Japan) · 2020Observational
- Lymph Node Ratio Predicts Long-Term Survival in Lymph Node-Positive Breast Cancer.European journal of breast health · 2020Article
- Gene expression comparison between primary triple-negative breast cancer and paired axillary and sentinel lymph node metastasis.The breast journal · 2020Article
- Integration of Ki-67 index into AJCC 2018 staging provides additional prognostic information in breast tumours candidate for genomic profiling.British journal of cancer · 2020Article
- Integration the biologic factors into the staging of breast cancer patients with ipsilateral supraclavicular lymph node metastasis.Journal of Cancer · 2020Article
- Clinical and molecular prognostic markers of survival after surgery for gastric cancer: tumor-node-metastasis staging system and beyond.Translational gastroenterology and hepatology · 2019Review
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4 authors.
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Abstract
The authors investigated the clinical utility of the revised prognostic staging system proposed in the eighth edition of the American Joint Committee on Cancer (AJCC) staging manual in breast cancer (BC) patients. We retrospectively reviewed the data of 714 BC patients that received surgical treatment and standard adjuvant therapy from January 2005 to December 2007. All patients were restaged for anatomic TNM stage and pathological prognostic (PP) stage as defined in the revised eighth edition of the AJCC manual. Compared with anatomic stage, PP stage was different from anatomic stage in 325 (45.5%) patients, 254 were down-staged and 71 were upstaged. There were significant differences in overall survival (OS) and disease-free survival (DFS) according to different anatomic stages or PP stages (all, p < 0.001). In anatomic stage I patients, OS was significantly different between PP stages IA and IB (p < 0.001), but no significant difference was observed between anatomic stages IA and IB (p = 0.413). PP stages exhibited significant OS differences in anatomic stage IIB (p = 0.011), but survival differences according to PP stages were not observed in anatomic stage IIA, IIIA, or IIIC. PP stages were found to have prognostic value with respect to OS and DFS for luminal (p < 0.001 and p < 0.001), HER2-positive (p = 0.001 and p = 0.013), and triple-negative (p = 0.008 and p = 0.03) subtypes. The prognostic staging system proposed in the eighth edition of the AJCC more accurately predicts the clinical outcomes of BC patients than the traditional anatomic staging system.
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