ArticleBioMedicine2018
Study of the effect of the essential oil (extract) of rhubarb stem (shoot) on glycosylated hemoglobin and fasting blood glucose levels in patients with type II diabetes.
Article in BioMedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- Active ingredients, nutrition values and health-promoting effects of aboveground parts of rhubarb: a review.Food science and biotechnology · 2026Review
- Antiobesity and antidiabetes effects ofHeliyon · 2024Article
- Exosomes from bone marrow mesenchymal stem cells ameliorate glucocorticoid-induced osteonecrosis of femoral head by transferring microRNA-210 into bone microvascular endothelial cells.Journal of orthopaedic surgery and research · 2023Article
- Activation of PI3K/Akt mediates the protective effect of diallyl trisulfide on doxorubicin induced cardiac apoptosis.Current research in toxicology · 2023Article
- A Review on Rhubarb-Derived Substances as Modulators of Cardiovascular Risk Factors-A Special Emphasis on Anti-Obesity Action.Nutrients · 2022Review
- Development of a Colloidal Gold Immunochromatographic Strip for the One-Step Evaluation of the Total Content of Rhein and Aloe-Emodin in Rhubarb.International journal of analytical chemistry · 2022Article
- Jowiseungki decoction affects diabetic nephropathy in mice through renal injury inhibition as evidenced by network pharmacology and gut microbiota analyses.Chinese medicine · 2020Article
- What we already know about rhubarb: a comprehensive review.Chinese medicine · 2020Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes is a serious chronic disease that can damage the heart, arteries, eyes, kidneys and nerves, leading to death and early disability. Before the discovery of insulin as well as common anti-diabetes drugs, patients with diabetes were treated with medicinal herbs and traditional treatments. One of these effective medicinal herbs is Rhubarb. Rhubarb is prescribed in traditional medicine for various patients, including patients with diabetes. But its effect has not been scientifically reported so far. PURPOSE: This study was conducted with the aim to determine the effectiveness of Rhubarb stem extract on HbA1C and fasting blood glucose in patients with type II diabetes.
methodIn this experimental study, 80 patients with type II diabetes mellitus in Zabol diabetes center, aged 30-60 years old with fasting blood glucose greater than 140 mg/d/ were selected. Patients were randomly assigned into two groups (n = 40) of treatment with capsules of Rhubarb stem and placebo after matching the oral medications. The patients in both groups were studied for fasting blood glucose and HbA1C before and after 1 month of conducting the study.
resultsThe mean FBS and HbA1C in rhubarb group before the intervention were 288.80 ± 94.49 and 9.62 ± 1.58, respectively, and after the intervention were 226.42 ± 88.89 and 7.83 ± 1.50, respectively. According to the statistical paired f-test and Wilcoxon test a significant reduction was found in FBS and HbA1C with rhubarb intervention (p < 0.05).
conclusionIn diabetes mellitus, as many factors affect the level of blood glucose, they also contribute to reducing blood glucose level and preventing complications. Therefore, considering the positive effects of rhubarb, it can be recommended to use rhubarb extract as an additional treatment to reduce blood glucose level.
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