ArticleLipids in health and disease2018
Association between serum lipids and low back pain among a middle-aged Japanese population: a large-scale cross-sectional study.
Article in Lipids in health and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Serum lipids and low back pain in male aircraft maintenance technicians: association after ergonomic exposure adjustment.Journal of occupational health · 2026Article
- Relationship between hyperlipidemia and lumbar disc degeneration in patients with low back pain: an observational retrospective study.Frontiers in physiology · 2026Article
- Association between metabolic syndrome and risk of incident low back pain: A retrospective cohort study using real-world data from Japan.Preventive medicine reports · 2025Article
- Association between metabolic syndrome and low back pain: a two-sample Mendelian randomization study.Scientific reports · 2025Article
- Genome-wide association study on chronic postsurgical pain after abdominal surgeries in the UK Biobank.Anaesthesia · 2025Article
- Association between lifestyle-related factors and low back pain: Evidence from a Japanese population-based study.PloS one · 2025Article
- Lipid metabolic disorders and their impact on cartilage endplate and nucleus pulposus function in intervertebral disk degeneration.Frontiers in nutrition · 2025Review
- Association between lipid-lowering agents with intervertebral disc degeneration, sciatica and low back pain: a drug-targeted mendelian randomized study and cross-sectional observation.Lipids in health and disease · 2024Observational
- Dyslipidemia Is Positively Associated with Chronic Low Back Pain in Korean Women: Korean National Health and Nutrition Examination Survey 2010-2012.Healthcare (Basel, Switzerland) · 2024Article
- Assessing the causal relationship between blood metabolites and low back pain: a Mendelian randomization study.American journal of translational research · 2024Article
- Association between HDL-C and chronic pain: data from the NHANES database 2003-2004.Frontiers in medicine · 2024Article
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- The impact of dyslipidemia on lumbar intervertebral disc degeneration and vertebral endplate modic changes: a cross-sectional study of 1035 citizens in China.BMC public health · 2023Article
- The Importance of Nutrition as a Lifestyle Factor in Chronic Pain Management: A Narrative Review.Journal of clinical medicine · 2022Review
- Impact of dyslipidemia on the severity of symptomatic lumbar spine degeneration: A retrospective clinical study.Frontiers in nutrition · 2022Article
- Cholesterol Induces Pyroptosis and Matrix DegradationFrontiers in cell and developmental biology · 2021Article
- Hepatic Steatosis Index and Chronic Kidney Disease among Middle-Aged Individuals: A Large-Scale Study in Japan.Disease markers · 2021Article
- Hypoxic stress enhances extension and branching of dorsal root ganglion neuronal outgrowth.JOR spine · 2020Article
- Sex differences in the association of metabolic syndrome with low back pain among middle-aged Japanese adults: a large-scale cross-sectional study.Biology of sex differences · 2019Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAbnormal lipid levels have been suggested as a mechanism leading to atherosclerosis of the lumbar vessels, resulting in low back pain (LBP). This study examined whether abnormal lipid levels were associated with LBP among middle-aged adults in Japan.
methodsThe present study included adults between 40 and 64 years old who underwent an annual health checkup. A total of 258,367 eligible participants were analyzed to investigate associations of LBP with low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and LDL-C/HDL-C ratio. Participants were categorized into two groups according to each of LDL-C, HDL-C, and LDL-C/HDL-C ratio (LDL-C: ≥ 140 vs. < 140 mg/dL; HDL-C: ≥ 40 vs. < 40 mg/dL; LDL-C/HDL-C ratio: ≥ 2.5 vs. < 2.5). Information on LBP was obtained using a self-administered questionnaire. Logistic regression modeling was used to calculate the odds ratio (OR) and 95% confidence interval (CI) for LBP.
resultsThe prevalence of LBP was 2.2% in men and 2.1% in women. Multivariable analysis adjusting for age, body mass index, and lifestyle factors found significant associations for HDL-C < 40 mg/dL (OR, 1.34; 95%CI, 1.20-1.48 in men; OR, 1.32; 95%CI, 1.02-1.72 in women) and LDL-C/HDL-C ratio ≥ 2.5 (OR, 1.17; 95%CI, 1.09-1.26 in men; OR, 1.15; 95%CI, 1.03-1.29 in women) with LBP.
conclusionsLow HDL-C and high LDL-C/HDL-C ratio were significantly associated with LBP in a middle-aged Japanese population. These findings might support the atherosclerosis-LBP hypothesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.