Evidence map›Paper›PMID 30474437›Full record

ArticleDrug delivery2018

Dual-modified natural high density lipoprotein particles for systemic glioma-targeting drug delivery.

Lin Cui, Yuli Wang, Meng Liang, Xiaoyang Chu, Shiyao Fu, Chunsheng Gao, Qianqian Liu, Wei Gong, Meiyan Yang, Zhiping Li and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Lin Cuia Jiamusi University , Jiamusi , China.
Yuli Wangb State Key Laboratory of Toxicology and Medical Countermeasures , Beijing Institute of Pharmacology and Toxicology , Beijing , China.
Meng Liangb State Key Laboratory of Toxicology and Medical Countermeasures , Beijing Institute of Pharmacology and Toxicology , Beijing , China.
Xiaoyang Chuc 307 Hospital of the PLA , Beijing , China.
Shiyao Fua Jiamusi University , Jiamusi , China.
Chunsheng Gaob State Key Laboratory of Toxicology and Medical Countermeasures , Beijing Institute of Pharmacology and Toxicology , Beijing , China.
Qianqian Liub State Key Laboratory of Toxicology and Medical Countermeasures , Beijing Institute of Pharmacology and Toxicology , Beijing , China.
Wei Gongb State Key Laboratory of Toxicology and Medical Countermeasures , Beijing Institute of Pharmacology and Toxicology , Beijing , China.
Meiyan Yangb State Key Laboratory of Toxicology and Medical Countermeasures , Beijing Institute of Pharmacology and Toxicology , Beijing , China.
Zhiping Lib State Key Laboratory of Toxicology and Medical Countermeasures , Beijing Institute of Pharmacology and Toxicology , Beijing , China.
Lian Yua Jiamusi University , Jiamusi , China.
Chunrong Yanga Jiamusi University , Jiamusi , China.
Zhide Sud Weifang People's Hospital , Weifang , China.
Xiangyang Xiee Department of Pharmacy , Wuhan General Hospital of the PLA , Wuhan , China.
Yang Yangb State Key Laboratory of Toxicology and Medical Countermeasures , Beijing Institute of Pharmacology and Toxicology , Beijing , China.
Chunsheng Gaob State Key Laboratory of Toxicology and Medical Countermeasures , Beijing Institute of Pharmacology and Toxicology , Beijing , China.
Jiamusi University · CNPLA 306 Hospital · CNWeifang People's Hospital · CNWuhan General Hospital of Guangzhou · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therapeutic outcome for the treatment of glioma was often limited due to the two barriers involved: the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB). Therefore, the development of nanocarriers that possess both BBB and BBTB permeability and glioma-targeting ability is of great importance for the chemotherapy of glioma. New frontiers in nanomedicine are advancing the research of new biomaterials. Here we constructed a natural high-density lipoprotein particle (HDL)-based drug delivery system with the dual-modification of T7 and

Indexed as

AnimalsAntineoplastic Agents, PhytogenicBlood-Brain BarrierBrain NeoplasmsCamptothecinCell Line, TumorCell SurvivalDrug CarriersDrug Delivery SystemsDrug LiberationFemaleGliomaHumansHuman Umbilical Vein Endothelial CellsLipoproteins, HDLMale10-hydroxycamptothecinAntineoplastic Agents, PhytogenicCamptothecinDrug CarriersLipoproteins, HDLPeptide Fragments10-hydroxycamptothecinblood-brain barrierblood-brain tumor barriergliomaNatural high-density lipoprotein particles

Identifiers

PMID30474437
PMCPMC6263114
OpenAlexW2902738044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.