Evidence map›Paper›PMID 30474117›Full record

ArticleJournal of anatomy2019

Sequential testicular atrophy involves changes in cellular proliferation and apoptosis associated with variations in aromatase P450 expression levels in Irs-2-deficient mice.

Leonardo Catalano-Iniesta, Virginia Sánchez-Robledo, Maria Carmen Iglesias-Osma, Maria José García-Barrado, Marta Carretero-Hernández, Enrique J Blanco, Teresa Vicente-García, Deborah Jane Burks, José Carretero

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of anatomy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. New Insight Into Male Infertility: Deviation From Basic Tenets of Life.Oxidative medicine and cellular longevity · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Leonardo Catalano-IniestaFaculty of Medicine, Department of Human Anatomy and Histology, Laboratory of Neuroendocrinology of the Institute of Neurosciences of Castilla y León (INCyL), Laboratory of Neuroendocrinology and Obesity of the Institute of Biomedical Research of Salamanca (IBSAL), University of Salamanca, Salamanca, Spain.
Virginia Sánchez-RobledoFaculty of Medicine, Department of Physiology and Pharmacology, Laboratory of Neuroendocrinology of the Institute of Neurosciences of Castilla y León (INCyL), Laboratory of Neuroendocrinology and Obesity of the Institute of Biomedical Research of Salamanca (IBSAL), University of Salamanca, Salamanca, Spain.
Maria Carmen Iglesias-OsmaFaculty of Medicine, Department of Physiology and Pharmacology, Laboratory of Neuroendocrinology of the Institute of Neurosciences of Castilla y León (INCyL), Laboratory of Neuroendocrinology and Obesity of the Institute of Biomedical Research of Salamanca (IBSAL), University of Salamanca, Salamanca, Spain.
Maria José García-BarradoFaculty of Medicine, Department of Physiology and Pharmacology, Laboratory of Neuroendocrinology of the Institute of Neurosciences of Castilla y León (INCyL), Laboratory of Neuroendocrinology and Obesity of the Institute of Biomedical Research of Salamanca (IBSAL), University of Salamanca, Salamanca, Spain.
Marta Carretero-HernándezFaculty of Medicine, Department of Human Anatomy and Histology, Laboratory of Neuroendocrinology of the Institute of Neurosciences of Castilla y León (INCyL), Laboratory of Neuroendocrinology and Obesity of the Institute of Biomedical Research of Salamanca (IBSAL), University of Salamanca, Salamanca, Spain.
Enrique J BlancoFaculty of Medicine, Department of Human Anatomy and Histology, Laboratory of Neuroendocrinology of the Institute of Neurosciences of Castilla y León (INCyL), Laboratory of Neuroendocrinology and Obesity of the Institute of Biomedical Research of Salamanca (IBSAL), University of Salamanca, Salamanca, Spain.ORCID 0000-0002-5332-4282
Teresa Vicente-GarcíaFaculty of Medicine, Department of Human Anatomy and Histology, Laboratory of Neuroendocrinology of the Institute of Neurosciences of Castilla y León (INCyL), Laboratory of Neuroendocrinology and Obesity of the Institute of Biomedical Research of Salamanca (IBSAL), University of Salamanca, Salamanca, Spain.
Deborah Jane BurksLaboratory of Molecular Neuroendocrinology, Centro de Investigación Príncipe Felipe, Valencia, Spain.
José CarreteroFaculty of Medicine, Department of Human Anatomy and Histology, Laboratory of Neuroendocrinology of the Institute of Neurosciences of Castilla y León (INCyL), Laboratory of Neuroendocrinology and Obesity of the Institute of Biomedical Research of Salamanca (IBSAL), University of Salamanca, Salamanca, Spain.
Universidad de Salamanca · ESCentro de Investigacion Principe Felipe · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insulin receptor substrate 2 (Irs-2) is an intracellular protein susceptible to phosphorylation after activation of the insulin receptor. Its suppression affects testis development and its absence induces peripheral resistance to insulin. The aim of this study was to identify changes induced by the deletion of Irs-2 in the testicular structure and by the altered expression of cytochrome P450 aromatase, a protein necessary for the development and maturation of germ cells. Adult knockout (KO) mice (Irs-2

Indexed as

SpermatogenesisAnimalsApoptosisAromataseAtrophyCell ProliferationHyperglycemiaInsulin Receptor Substrate ProteinsMaleMice, Inbred C57BLMice, KnockoutTestisAromataseInsulin Receptor Substrate ProteinsIrs2 protein, mouseapoptosisaromatasecellular proliferationinsulin receptor substrate 2testis

Identifiers

PMID30474117
PMCPMC6326910
OpenAlexW2902354388

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.