Evidence map›Paper›PMID 30474080›Full record

ArticleACS applied bio materials2018

A Layer-by-Layer Approach To Retain a Fluorescent Glucose Sensing Assay within the Cavity of a Hydrogel Membrane.

Andrea K Locke, Anna Kristen Means, Ping Dong, Tyler J Nichols, Gerard L Coté, Melissa A Grunlan

Open access · bronzeAbstract read
In one paragraph

Article in ACS applied bio materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Andrea K LockeDepartment of Biomedical Engineering, Department of Materials Science and Engineering, Department of Chemistry, and Center for Remote Healthcare Technologies, Texas A&M University, College Station, Texas 77843-3120, United States.
Anna Kristen MeansDepartment of Biomedical Engineering, Department of Materials Science and Engineering, Department of Chemistry, and Center for Remote Healthcare Technologies, Texas A&M University, College Station, Texas 77843-3120, United States.
Ping DongDepartment of Biomedical Engineering, Department of Materials Science and Engineering, Department of Chemistry, and Center for Remote Healthcare Technologies, Texas A&M University, College Station, Texas 77843-3120, United States.
Tyler J NicholsDepartment of Biomedical Engineering, Department of Materials Science and Engineering, Department of Chemistry, and Center for Remote Healthcare Technologies, Texas A&M University, College Station, Texas 77843-3120, United States.
Gerard L CotéDepartment of Biomedical Engineering, Department of Materials Science and Engineering, Department of Chemistry, and Center for Remote Healthcare Technologies, Texas A&M University, College Station, Texas 77843-3120, United States.
Melissa A GrunlanDepartment of Biomedical Engineering, Department of Materials Science and Engineering, Department of Chemistry, and Center for Remote Healthcare Technologies, Texas A&M University, College Station, Texas 77843-3120, United States.
Texas A&M University · US

Funding

A Self-Cleaning Membrane to Extend the Lifetime of an Implanted Glucose BiosensorR01DK095101 · NIDDK · TEXAS ENGINEERING EXPERIMENT STATION · PI GRUNLAN, MELISSA · 2012 to 2016
$1.6M
NIDDK NIH HHS R01 DK095101
6 · The paper itself

Abstract

A continuous glucose monitoring device that resides fully in the subcutaneous tissue has the potential to greatly improve the management of diabetes. Toward this goal, we have developed a competitive binding glucose sensing assay based on fluorescently labeled PEGylated concanavalin-A (PEGylated-TRITC-ConA) and mannotetraose (APTS-MT). In the present work, we sought to contain this assay within the hollow central cavity of a cylindrical hydrogel membrane, permitting eventual subcutaneous implantation and optical probing through the skin. A "self-cleaning" hydrogel was utilized because of its ability to cyclically deswell/reswell in vivo, which is expected to reduce biofouling and therefore extend the sensor lifetime. Thus, we prepared a hollow, cylindrical hydrogel based on a thermoresponsive electrostatic double network design composed of

Identifiers

PMID30474080
PMCPMC6247246
OpenAlexW2896403865

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.