Evidence map›Paper›PMID 30474074›Full record

ArticleJAMIA open2018

A Curated Cancer Clinical Outcomes Database (C3OD) for accelerating patient recruitment in cancer clinical trials.

Dinesh Pal Mudaranthakam, Jeffrey Thompson, Jinxiang Hu, Dong Pei, Shanthan Reddy Chintala, Michele Park, Brooke L Fridley, Byron Gajewski, Devin C Koestler, Matthew S Mayo

Abstract read
In one paragraph

Article in JAMIA open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dinesh Pal MudaranthakamDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas, USA.
Jeffrey ThompsonDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas, USA.
Jinxiang HuDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas, USA.
Dong PeiDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas, USA.
Shanthan Reddy ChintalaDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas, USA.
Michele ParkUniversity of Kansas Cancer Center, Kansas City, Kansas, USA.
Brooke L FridleyDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, USA.
Byron GajewskiDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas, USA.
Devin C KoestlerDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas, USA.
Matthew S MayoDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas, USA.

Funding

Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NICOLE L NOLLEN · 2012 to 2026
$40.1M
NCI NIH HHS P30 CA168524
6 · The paper itself

Abstract

Data used to determine patient eligibility for cancer clinical trials often come from disparate sources that are typically maintained by different groups within an institution, use differing technologies, and are stored in different formats. Collecting data and resolving inconsistencies across sources increase the time it takes to screen eligible patients, potentially delaying study completion. To address these challenges, the Biostatistics and Informatics Shared Resource at The University of Kansas Cancer Center developed the Curated Cancer Clinical Outcomes Database (C3OD). C3OD merges data from the electronic medical record, tumor registry, bio-specimen and data registry, and allows querying through a single unified platform. By centralizing access and maintaining appropriate controls, C3OD allows researchers to more rapidly obtain detailed information about each patient in order to accelerate eligibility screening. This case report describes the design of this informatics platform as well as initial assessments of its reliability and usability.

Indexed as

automated eligibility screeningclinical research informaticspatient recruitment

Identifiers

PMID30474074
PMCPMC6241508

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.