ArticleScience advances2018
Strain-triggered mechanical feedback in self-organizing optic-cup morphogenesis.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Biophysics of lumen morphogenesis.Development (Cambridge, England) · 2026Review
- The role of geometry in morphogenesis.Development (Cambridge, England) · 2026Review
- Wilhelm Hofmeister revisited: Meristematic surfaces channel information flows in organogenesis.Quantitative plant biology · 2026Review
- Simultaneous generation of transplantable RGC-like and corneal progenitor cells from hiPSCs using a dual-lineage platform.Stem cell research & therapy · 2025Article
- Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Vertex models capturing subcellular scales in epithelial tissues.PLoS computational biology · 2025Review
- Mechanochemical bistability of intestinal organoids enables robust morphogenesis.Nature physics · 2025Article
- An actin bracket-induced elastoplastic transition determines epithelial folding irreversibility.Nature communications · 2024Article
- Article
- Article
- An agent-based modelling framework to study growth mechanisms inRoyal Society open science · 2024Article
- Organoid intelligence: Integration of organoid technology and artificial intelligence in the new era of in vitro models.Medicine in novel technology and devices · 2024Article
- Machine learning-based estimation of spatial gene expression pattern during ESC-derived retinal organoid development.Scientific reports · 2023Article
- Shape-driven confluent rigidity transition in curved biological tissues.Biophysical journal · 2023Article
- Mathematical modeling for developmental processes.Development, growth & differentiation · 2023Review
- Ontogeny of collective behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Optic cup morphogenesis across species and related inborn human eye defects.Development (Cambridge, England) · 2023Review
- Human Stem Cells for Ophthalmology: Recent Advances in Diagnostic Image Analysis and Computational Modelling.Current stem cell reports · 2023Review
- Organoid Cultures In Silico: Tools or Toys?Bioengineering (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organogenesis is a self-organizing process of multiple cells in three-dimensional (3D) space, where macroscopic tissue deformations are robustly regulated by multicellular autonomy. It is clear that this robust regulation requires cells to sense and modulate 3D tissue formation across different scales, but its underlying mechanisms are still unclear. To address this question, we developed a versatile computational model of 3D multicellular dynamics at single-cell resolution and combined it with the 3D culture system of pluripotent stem cell-derived optic-cup organoid. The complementary approach enabled quantitative prediction of morphogenesis and its corresponding verification and elucidated that the macroscopic 3D tissue deformation is fed back to individual cellular force generations via mechanosensing. We hereby conclude that mechanical force plays a key role as a feedback regulator to establish the robustness of organogenesis.
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Registered trials
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