ArticleCase reports in endocrinology2018
Marine-Lenhart Syndrome: Case Report, Diagnosis, and Management.
Article in Case reports in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Thyrotoxicosis-Associated Cholestatic Jaundice in a Patient With Incidental Gallstone Disease: A Case Report and Literature Review.The American journal of case reports · 2026Review
- Synchronous Presentation of Type 2 Marine-Lenhart Syndrome and Differentiated Thyroid Carcinoma Manifesting as Thyroid Storm.Case reports in endocrinology · 2025Article
- Unilateral Graves' Orbitopathy in a Patient with Marine-Lenhart Syndrome: A case report.Sultan Qaboos University medical journal · 2024Article
- Marine-Lenhart syndrome with a cold nodule: an uncommon entity.BMJ case reports · 2022Article
- Article
- Prevalence and Treatment Outcomes of Marine-Lenhart Syndrome in Japan.European thyroid journal · 2021Article
- Recurrent Goiter Presented with Marine-Lenhart Syndrome 27 Years After Initial Surgery.Cureus · 2019Article
- MARINE LENHART SYNDROME WITH THYROID ISTHMUS AGENESIA. A NEW SYNDROME?Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The coexistence of thyroid functioning nodules and Graves' disease is called Marine-Lenhart syndrome. This condition is estimated to occur in 0.8-2.7% of patients with Graves' disease with few cases reported in the literature. Criteria for the diagnosis are not well defined. Here, we present a case of hyperthyroidism characterized by the presence of stimulating TSH receptor antibodies and severe bilateral exophthalmos. A thyroid uptake and scan revealed an elevated 24-hour iodine-131 uptake and a discrete hot nodule in the upper pole of the right lobe which was also observed with a thyroid ultrasound. The patient was diagnosed with Marine-Lenhart syndrome complicated by thyroid eye disease and was treated with methimazole followed by thyroidectomy and orbital decompression. We review the existing literature and propose criteria for the diagnosis and treatment of this condition.
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Registered trials
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