ArticleBasic and clinical andrology2018
Effects of lipopolysaccharide-induced inflammation on hypoxia and inflammatory gene expression pathways of the rat testis.
Article in Basic and clinical andrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
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- Zinc and animal health: an in-depth exploration of its role in physiological functions and regulatory molecular mechanisms.Journal of animal science and biotechnology · 2025Review
- Contribution and Regulation of HIF-1α in Testicular Injury Induced by Diabetes Mellitus.Biomolecules · 2025Review
- Monosodium glutamate exacerbated the lipopolysaccharide-induced reproductive toxicity of male Wistar rats.BMC pharmacology & toxicology · 2025Article
- Gallic acid mitigates lipopolysaccharide-induced testicular inflammation via regulation of the NF-κB and PK2/PKR1 pathway.Journal of molecular histology · 2025Article
- Patterns of alteration in boar semen quality from 9 to 37 months old and improvement by protocatechuic acid.Journal of animal science and biotechnology · 2024Article
- Gut microbiota is involved in male reproductive function: a review.Frontiers in microbiology · 2024Review
- Infertility in Fabry's Disease: role of hypoxia and inflammation in determining testicular damage.Frontiers in endocrinology · 2024Article
- Roxadustat (FG-4592) abated lipopolysaccharides-induced depressive-like symptomsFrontiers in molecular neuroscience · 2023Article
- The potential impact of COVID-19 on male reproductive health.Journal of endocrinological investigation · 2022Review
- Understanding the Underlying Molecular Mechanisms of Meiotic Arrest during In Vitro Spermatogenesis in Rat Prepubertal Testicular Tissue.International journal of molecular sciences · 2022Article
- Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia.Nature communications · 2021Article
- Elucidation of the Hdac2/Sp1/Molecular therapy. Nucleic acids · 2021Article
- Bacterial Infections Affect Male Fertility: A Focus on the Oxidative Stress-Autophagy Axis.Frontiers in cell and developmental biology · 2021Review
- Effects of inflammatory and anti-inflammatory environments on the macrophage mitochondrial function.Scientific reports · 2020Article
- Differential expression of genes associated with T lymphocytes function in septic patients with hypoxemia challenge.Annals of translational medicine · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundBacterial infection and inflammation of the testis impairs fertility, yet an understanding of inflammatory responses of the testis is incomplete. We are interested in identifying gene pathways involved in the detection and clearance of infectious microbes in the male reproductive tract. In previous studies in our lab focused on hypoxia-responsive genes of the testis, preliminary experiments suggested that genes classically categorized as hypoxia genes are also activated during antimicrobial responses. The purpose of this study was to identify hypoxia and inflammatory gene pathways that contribute to antimicrobial protection of the testis and to consider possible cross-talk and interactions between these pathways. Inflammation was induced in Sprague-Dawley rats using
resultsIn LPS-treated rats, HIF-1α protein increased with no change in
conclusionsTesticular HIF-1α is up-regulated following LPS-induced inflammation. In contrast to other tissues, in which HIF-1α is up-regulated through transcriptional activation via NF-κB, we conclude that HIF-1α in the testis is not up-regulated through an increase in
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Registered trials
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