Evidence map›Paper›PMID 30473705›Full record

ArticleFrontiers in genetics2018

Validation of a Salivary RNA Test for Childhood Autism Spectrum Disorder.

Steven D Hicks, Alexander T Rajan, Kayla E Wagner, Sarah Barns, Randall L Carpenter, Frank A Middleton

3 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 36 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02832557 completednot on this map

Validation of a Salivary miRNA Diagnostic Test for Autism Spectrum Disorder

TypeobservationalSponsorState University of New York - Upstate Medical UniversityRan2015 to 2021Enrolled998ConditionsAutism Spectrum Disorder, Developmental DelayArmsSalivary collection, Vineland Adaptive Behavior Scale-III Assessment, Medical history questionaire, Autism Diagnostic Observation Schedule -2nd edition (ADOS-2), Mullen Scales of Early Learning
NCT05418023 unknown statusnot on this mapstarted 2022, after this paper: background citation

Validation of a Salivary miRNA Diagnostic Test for Autism Spectrum Disorder

TypeobservationalSponsorQuadrant Biosciences Inc.Ran2022 to 2023Enrolled6,604ConditionsAutism Spectrum Disorder, Developmental DelayArmsSalivary Collection, Adaptive Assessment, Medical and Demographic questionnaire, Autism Assessment, Intellectual Development Assessment
NCT05796310 unknown statusnot on this mapstarted 2022, after this paper: background citation

Mind the Gap: a Bridge Between Research and Clinic for the Prevention and Diagnosis of Autism Spectrum Disorders

TypeobservationalSponsorIRCCS Centro Neurolesi Bonino PulejoRan2022 to 2025Enrolled28ConditionsAutism Spectrum DisorderArmsSalivary collection, eye-tracking recorder, neuropsychological assessment
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Potential of Salivary Biomarkers in Autism Research: A Systematic Review.International journal of molecular sciences · 2021
    Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Comparison of MicroRNA Levels of 18-60-month-old Autistic Children with Those of Their Siblings and Controls.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. RNA biomarkers for alcohol use disorder.Frontiers in molecular neuroscience · 2022
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Steven D HicksDepartment of Pediatrics, Penn State College of Medicine, Hershey, PA, United States.
Alexander T RajanQuadrant Biosciences, Inc., Syracuse, NY, United States.
Kayla E WagnerQuadrant Biosciences, Inc., Syracuse, NY, United States.
Sarah BarnsQuadrant Biosciences, Inc., Syracuse, NY, United States.
Randall L CarpenterQuadrant Biosciences, Inc., Syracuse, NY, United States.
Frank A MiddletonDepartments of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY, United States.
SUNY Upstate Medical University · USPenn State Milton S. Hershey Medical Center · US

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
Penn State Institutional Career Development CoreKL2TR002015 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI VAN SCOY, LAUREN JODI · 2016 to 2025
$7.8M
Validation of a salivary miRNA diagnostic test for autism spectrum disorderR42MH111347 · NIMH · QUADRANT BIOSCIENCES, INC. · PI DU, QIAN, FRAZIER, THOMAS WILLIAM · 2018 to 2020
$2.2M
Validation of a salivary miRNA diagnostic test for autism spectrum disorderR41MH111347 · NIMH · QUADRANT BIOSCIENCES, INC. · PI MIDDLETON, FRANK A. · 2016 to 2016
$225k
NCATS NIH HHS KL2 TR002015NCATS NIH HHS UL1 TR002014NIMH NIH HHS R41 MH111347NIMH NIH HHS R42 MH111347
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

autismdiagnosisepigeneticsmachine learningmicroRNARNAscreeningtranscriptome

Identifiers

PMID30473705
PMCPMC6237842
OpenAlexW2899762601

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.