Evidence map›Paper›PMID 30473658›Full record

ArticleAdvanced functional materials2018

Photoacoustic Imaging of Embryonic Stem Cell-Derived Cardiomyocytes in Living Hearts with Ultrasensitive Semiconducting Polymer Nanoparticles.

Xulei Qin, Haodong Chen, Huaxiao Yang, Haodi Wu, Xin Zhao, Huiyuan Wang, Tony Chour, Evgenios Neofytou, Dan Ding, Heike Daldrup-Link and 3 more

Abstract read
In one paragraph

Article in Advanced functional materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Review
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  5. Article
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  8. Nanotechnology in interventional cardiology: A state-of-the-art review.International journal of cardiology. Heart & vasculature · 2022
    Review
  9. Article
  10. Article
  11. Review
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  16. Review
  17. Engineered Matrices Enable the Culture of Human Patient-Derived Intestinal Organoids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
  18. Article
  19. Chemical science · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xulei Qin *Stanford Cardiovascular Institute, Stanford, CA, 94305, United States.
Haodong Chen *Stanford Cardiovascular Institute, Stanford, CA, 94305, United States.
Huaxiao Yang *Stanford Cardiovascular Institute, Stanford, CA, 94305, United States.
Haodi WuStanford Cardiovascular Institute, Stanford, CA, 94305, United States.
Xin ZhaoStanford Cardiovascular Institute, Stanford, CA, 94305, United States.
Huiyuan WangDepartment of Materials Science and Engineering, Stanford, CA, 94305, United States.
Tony ChourStanford Cardiovascular Institute, Stanford, CA, 94305, United States.
Evgenios NeofytouStanford Cardiovascular Institute, Stanford, CA, 94305, United States.
Dan DingState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, China, 300071.
Heike Daldrup-LinkDepartment of Radiology, Stanford, CA, 94305, United States.
Sarah C HeilshornDepartment of Materials Science and Engineering, Stanford, CA, 94305, United States.
Kai LiDepartment of Radiology, Stanford, CA, 94305, United States.
Joseph C WuStanford Cardiovascular Institute, Stanford, CA, 94305, United States.

Funding

Progenitor Cell Biology Consortium Administrative Coordinating CenterU01HL099997 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI TERRIN, MICHAEL L · 2009 to 2015
$29.9M
Induced pluripotent stem cells in the understanding and treatment of heart diseaseU01HL099776 · NHLBI · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T, WU, JOSEPH C. · 2009 to 2015
$8.2M
PCTC Administrative Coordinating CenterU24HL134763 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI ALBRECHT, JENNIFER S., TERRIN, MICHAEL L · 2016 to 2022
$7.9M
Multi-Disciplinary Training Program in Cardiovascular Imaging at StanfordT32EB009035 · NIBIB · STANFORD UNIVERSITY · PI Koen Nieman, John M. Pauly · 2008 to 2026
$4.3M
Molecular Imaging of Cardiac Pluripotent Stem CellsR01HL133272 · NHLBI · STANFORD UNIVERSITY · PI WU, JOSEPH C. · 2016 to 2020
$2.4M
Assessment of Low-Dose Radiation Risk and Mechanisms of Individual RadiosensitivityR01HL132875 · NHLBI · STANFORD UNIVERSITY · PI WU, JOSEPH C. · 2016 to 2019
$1.9M
Upgrade of the Stanford GE-Varian Experimental MRI Scanner to the Current Model MS10RR026917 · NCRR · STANFORD UNIVERSITY · PI MOSELEY, MICHAEL E · 2010 to 2010
$497k
Injectable Hydrogels to Improve the Efficacy of iPSC-derived TherapiesR21EB020235 · NIBIB · STANFORD UNIVERSITY · PI HEILSHORN, SARAH C, HUANG, NGAN F. · 2015 to 2016
$433k
NCRR NIH HHS S10 RR026917NHLBI NIH HHS R01 HL132875NHLBI NIH HHS R01 HL133272NHLBI NIH HHS U01 HL099776NHLBI NIH HHS U01 HL099997NHLBI NIH HHS U24 HL134763NIBIB NIH HHS R21 EB020235NIBIB NIH HHS T32 EB009035
6 · The paper itself

Abstract

The last decade has seen impressive progress in human embryonic stem cell-derived cardiomyocytes (hESC-CMs) that makes them ideal tools to repair injured hearts. To achieve an optimal outcome, advanced molecular imaging methods are essential to accurately track these transplanted cells in the heart. Herein, we demonstrate for the first time that a class of photoacoustic nanoparticles (PANPs) incorporating semiconducting polymers (SPs) as contrast agents can be used in the photoacoustic imaging (PAI) of transplanted hESC-CMs in living mouse hearts. This is achieved by virtue of two benefits of PANPs. First, strong PA signals and specific spectral features of SPs allow PAI to sensitively detect and distinguish a small number of PANP-labeled cells (2,000) from background tissues

Indexed as

cardiac cell trackingcardiac regenerative therapyphotoacoustic imagingsemiconducting polymer

Identifiers

PMID30473658
PMCPMC6247950

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.