ArticleMetabolomics : Official journal of the Metabolomic Society2017
Applications of Metabolomics in the Study and Management of Preeclampsia; A Review of the Literature.
Article in Metabolomics : Official journal of the Metabolomic Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course: a multi-cohort study.BMC medicine · 2023Pooled it
- Novel Insights into the Causal Relationship between Antidiabetic Drugs and Adverse Perinatal Outcomes: A Mendelian Randomization Study.Diabetes & metabolism journal · 2025Article
- Heme oxygenase/carbon monoxide system affects the placenta and preeclampsia.Medical gas research · 2025Review
- Metabolomic Alterations Associated with Phthalate Exposures among Pregnant Women in Puerto Rico.Environmental science & technology · 2024Article
- Acylcarnitines are associated with lower depressive symptomatology in a mainland puerto rican cohort.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Metabolomic prediction of severe maternal and newborn complications in preeclampsia.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Relationship between the concentration of ergothioneine in plasma and the likelihood of developing pre-eclampsia.Bioscience reports · 2023Article
- Serum from patients with hypertension promotes endothelial dysfunction to induce trophoblast invasion through the miR‑27b‑3p/ATPase plasma membrane CaMolecular medicine reports · 2021Article
- Untargeted analysis of first trimester serum to reveal biomarkers of pregnancy complications: a case-control discovery phase study.Scientific reports · 2021Article
- Global metabolomic profiling reveals hepatic biosignatures that reflect the unique metabolic needs of late-term mother and fetus.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- The influence of pregnancy-induced hypertension syndrome on the metabolism of newborns.Translational pediatrics · 2021Article
- Nuclear Magnetic Resonance Spectroscopy in Clinical Metabolomics and Personalized Medicine: Current Challenges and Perspectives.Frontiers in molecular biosciences · 2021Review
- Metabolomics in the study of spontaneous animal diseases.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2020Review
- 4-Hydroxyglutamate is a novel predictor of pre-eclampsia.International journal of epidemiology · 2020Article
- Article
- Circulating Plasma Metabolites and Cognitive Function in a Puerto Rican Cohort.Journal of Alzheimer's disease : JAD · 2020Article
- Lipidomic profiling of chorionic villi in the placentas of women with chronic venous disease.International journal of medical sciences · 2020Observational
- Differences in Pregnancy Metabolic Profiles and Their Determinants between White European and South Asian Women: Findings from the Born in Bradford Cohort.Metabolites · 2019Article
- A double-hit pre-eclampsia model results in sex-specific growth restriction patterns.Disease models & mechanisms · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Introduction: Preeclampsia represents a major public health burden worldwide, but predictive and diagnostic biomarkers are lacking. Metabolomics is emerging as a valuable approach to generating novel biomarkers whilst increasing the mechanistic understanding of this complex condition. Objectives: To summarize the published literature on the use of metabolomics as a tool to study preeclampsia. Methods: PubMed and Web of Science were searched for articles that performed metabolomic profiling of human biosamples using either Mass-spectrometry or Nuclear Magnetic Resonance based approaches and which included preeclampsia as a primary endpoint. Results: Twenty-eight studies investigating the metabolome of preeclampsia in a variety of biospecimens were identified. Individual metabolite and metabolite profiles were reported to have discriminatory ability to distinguish preeclamptic from normal pregnancies, both prior to and post diagnosis. Lipids and carnitines were among the most commonly reported metabolites. Further work and validation studies are required to demonstrate the utility of such metabolites as preeclampsia biomarkers. Conclusion: Metabolomic-based biomarkers of preeclampsia have yet to be integrated into routine clinical practice. However, metabolomic profiling is becoming increasingly popular in the study of preeclampsia and is likely to be a valuable tool to better understand the pathophysiology of this disorder and to better classify its subtypes, particularly when integrated with other omic data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.