Evidence map›Paper›PMID 30473644›Full record

ArticleContrast media & molecular imaging2018

Fully Automated Delineation of Gross Tumor Volume for Head and Neck Cancer on PET-CT Using Deep Learning: A Dual-Center Study.

Bin Huang, Zhewei Chen, Po-Man Wu, Yufeng Ye, Shi-Ting Feng, Ching-Yee Oliver Wong, Liyun Zheng, Yong Liu, Tianfu Wang, Qiaoliang Li and 1 more

Abstract readMulticenter Study
In one paragraph

Article in Contrast media & molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. MRI-Based Head and Neck Tumor Segmentation Using nnU-Net with 15-Fold Cross-Validation Ensemble.Head and Neck Tumor Segmentation for MR-Guided Applications : First MICCAI Challenge, HNTS-MRG 2024, held in conjunction with MICCAI 2024, Marrakesh, Morocco, October 17, 2024, proceedings · 2025
    Article
  7. Artificial Intelligence in Head and Neck Surgery.Otolaryngologic clinics of North America · 2024
    Review
  8. Automated Segmentation of Sacral Chordoma and Surrounding Muscles Using Deep Learning Ensemble.International journal of radiation oncology, biology, physics · 2023
    Article
  9. Article
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  11. Review
  12. Article
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  14. Deep learning-based GTV contouring modeling inter- and intra- observer variability in sarcomas.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2022
    Article
  15. Automatic segmentation of head and neck primary tumors on MRI using a multi-view CNN.Cancer imaging : the official publication of the International Cancer Imaging Society · 2022
    Article
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  17. Article
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bin HuangSchool of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China.
Zhewei ChenSchool of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China.
Po-Man WuMedical Physics and Research Department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong.
Yufeng YeDepartment of Radiology, Guangzhou Panyu Central Hospital, Guangzhou, China.ORCID 0000-0002-9843-475X
Shi-Ting FengDepartment of Radiology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Ching-Yee Oliver WongUniversity of Southern California, Los Angeles, USA.
Liyun ZhengSchool of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China.
Yong LiuIntensive Care Unit, Southern Medical University Shenzhen Hospital, Shenzhen, China.
Tianfu WangSchool of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China.
Qiaoliang LiSchool of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China.ORCID 0000-0003-2876-4152
Bingsheng HuangSchool of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China.ORCID 0000-0002-1183-7506

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: In this study, we proposed an automated deep learning (DL) method for head and neck cancer (HNC) gross tumor volume (GTV) contouring on positron emission tomography-computed tomography (PET-CT) images. Materials and Methods: PET-CT images were collected from 22 newly diagnosed HNC patients, of whom 17 (Database 1) and 5 (Database 2) were from two centers, respectively. An oncologist and a radiologist decided the gold standard of GTV manually by consensus. We developed a deep convolutional neural network (DCNN) and trained the network based on the two-dimensional PET-CT images and the gold standard of GTV in the training dataset. We did two experiments: Experiment 1, with Database 1 only, and Experiment 2, with both Databases 1 and 2. In both Experiment 1 and Experiment 2, we evaluated the proposed method using a leave-one-out cross-validation strategy. We compared the median results in Experiment 2 (GTVa) with the performance of other methods in the literature and with the gold standard (GTVm). Results: A tumor segmentation task for a patient on coregistered PET-CT images took less than one minute. The dice similarity coefficient (DSC) of the proposed method in Experiment 1 and Experiment 2 was 0.481∼0.872 and 0.482∼0.868, respectively. The DSC of GTVa was better than that in previous studies. A high correlation was found between GTVa and GTVm ( Conclusion: A fully automatic GTV contouring method for HNC based on DCNN and PET-CT from dual centers has been successfully proposed with high accuracy and efficiency. Our proposed method is of help to the clinicians in HNC management.

Indexed as

Deep LearningModels, TheoreticalPositron Emission Tomography Computed TomographyFemaleHead and Neck NeoplasmsHumansMaleMiddle Aged

Identifiers

PMID30473644
PMCPMC6220410

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.