Evidence map›Paper›PMID 30473544›Full record

ArticleJournal of lipid research2019

Plasma proteome correlates of lipid and lipoprotein: biomarkers of metabolic diversity and inflammation in children of rural Nepal.

Sun Eun Lee, Kerry Schulze, Christine P Stewart, Robert N Cole, Lee S-F Wu, Abdulkerim Eroglu, James D Yager, John Groopman, Parul Christian, Keith P West

Open access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Carotenoids in Health as Studied by Omics-Related Endpoints.Advances in nutrition (Bethesda, Md.) · 2023
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sun Eun LeeCenter for Human Nutrition Johns Hopkins Bloomberg School of Public Health, Baltimore, MD slee278@jhu.edu.
Kerry SchulzeCenter for Human Nutrition Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Christine P StewartProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA.
Robert N ColeMass Spectrometry and Proteomics Facility, Johns Hopkins School of Medicine, Baltimore, MD.
Lee S-F WuCenter for Human Nutrition Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Abdulkerim ErogluCenter for Human Nutrition Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
James D YagerDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
John GroopmanDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Parul ChristianCenter for Human Nutrition Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Keith P WestCenter for Human Nutrition Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Johns Hopkins University · USUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proteins involved in lipoprotein metabolism can modulate cardiovascular health. While often measured to assess adult metabolic diseases, little is known about the proteomes of lipoproteins and their relation to metabolic dysregulation and underlying inflammation in undernourished child populations. The objective of this population study was to globally characterize plasma proteins systemically associated with HDL, LDL, and triglycerides in 500 Nepalese children. Abnormal lipid profiles characterized by elevated plasma triglycerides and low HDL-cholesterol (HDL-C) concentrations were common, especially in children with subclinical inflammation. Among 982 proteins analyzed, the relative abundance of 11, 12, and 52 plasma proteins was correlated with LDL-cholesterol (

Indexed as

ProteomicsRural PopulationBiomarkersChildFemaleHumansInflammationLipoproteinsMaleNepalBiomarkersLipoproteinshigh density lipoprotein-cholesterollow density lipoprotein-cholesterolplasma proteomicstriglycerides

Identifiers

PMID30473544
PMCPMC6314253
OpenAlexW2902525490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.