ArticleUltrasound in medicine & biology2019
Quantitative Ultrasound Biomarkers Based on Backscattered Acoustic Power: Potential for Quantifying Remodeling of the Human Cervix during Pregnancy.
Article in Ultrasound in medicine & biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Improved imaging interfaces on a co-registered ultrasound and optical microscopy multiscale system.Journal of biomedical optics · 2026Article
- Repeatability and reproducibility of quantitative ultrasound cervical measurements in women at risk for preterm birth.Discover imaging · 2025Article
- A Study on the Effects of Depth-Dependent Power Loss on Speckle Statistics Estimation.Ultrasound in medicine & biology · 2024Article
- Graduate Student Literature Review: Mammary gland development in dairy cattle-Quantifying growth and development.Journal of dairy science · 2024Review
- Analytic Global Regularized Backscatter Quantitative Ultrasound.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Challenges of conducting quantitative ultrasound with a multimodal optical imaging system.Physics in medicine and biology · 2021Article
- 3-D-Printed Registration Phantom for Combined Ultrasound and Optical Imaging of Biological Tissues.Ultrasound in medicine & biology · 2020Article
- Platform for quantitative multiscale imaging of tissue composition.Biomedical optics express · 2020Article
- Labour and delivery: a clinician's perspective on a biomechanics problem.Interface focus · 2019Article
- Quantitative Ultrasound Parameters Based on the Backscattered Echo Power Signal as Biomarkers of Cervical Remodeling: A Longitudinal Study in the Pregnant Rhesus Macaque.Ultrasound in medicine & biology · 2019Article
- Immunobiology of Cervix Ripening.Frontiers in immunology · 2019Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
As pregnancy progresses, the cervix remodels from a rigid structure to one pliable enough to allow delivery of a fetus, a process that involves progressive disorganization of cervical microstructure. Quantitative ultrasound biomarkers that may detect this process include those derived from the backscattered echo signal, namely, acoustic attenuation and backscattered power loss. We recently reported that attenuation and backscattered power loss are affected by tissue anisotropy and heterogeneity in the ex vivo cervix. In this study, we compared attenuation and backscattered power difference in a group of women in early pregnancy (first trimester) with those in a group in late pregnancy (third trimester). We observed a significant decrease in the backscattered power difference in late as compared with early pregnancy, suggesting decreased microstructural organization in late pregnancy, a finding that is consistent with animal models of cervical remodeling. In contrast, we found no difference in attenuation between the time points. These results suggest that the backscattered power difference, but perhaps not attenuation, may be a useful clinical biomarker of cervical remodeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.