Evidence map›Paper›PMID 30473131›Full record

ReviewHearing research2019

Tonotopy in calcium homeostasis and vulnerability of cochlear hair cells.

Robert Fettiplace, Jong-Hoon Nam

Open access · hybridAbstract readReview
In one paragraph

Review in Hearing research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Hair cell loss - cause or consequence of hearing loss?Frontiers in cell and developmental biology · 2026
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Hair cell apoptosis and deafness inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Article
  16. Pharmacological Approaches to Hearing Loss.Pharmacological reviews · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Robert FettiplaceDepartment of Neuroscience, University of Wisconsin, Madison, WI, 53706, USA. Electronic address: fettiplace@wisc.edu.
Jong-Hoon NamDepartments of Mechanical Engineering and Biomedical Engineering, University of Rochester, Rochester, NY, 14627, USA.
University of Rochester · USUniversity of Wisconsin–Madison · US

Funding

INTRACELLULAR CALCIUM IN HAIR CELLSR01DC001362 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERT FETTIPLACE · 1992 to 2026
$11.3M
The Role of the Organ of Corti for Cochlear Power TransmissionR01DC014685 · NIDCD · UNIVERSITY OF ROCHESTER · PI Jong-Hoon Nam · 2015 to 2026
$4.1M
The development of mechanotransduction in cochlear hair cellsR01DC015439 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI FETTIPLACE, ROBERT · 2016 to 2020
$2.0M
NIDCD NIH HHS R01 DC001362NIDCD NIH HHS R01 DC014685NIDCD NIH HHS R01 DC015439
6 · The paper itself

Abstract

Ototoxicity, noise overstimulation, or aging, can all produce hearing loss with similar properties, in which outer hair cells (OHCs), principally those at the high-frequency base of the cochlea, are preferentially affected. We suggest that the differential vulnerability may partly arise from differences in Ca

Indexed as

Acoustic StimulationAnimalsCalcium SignalingCell CompartmentationGerbillinaeHair Cells, AuditoryHair Cells, Auditory, InnerHair Cells, Auditory, OuterHomeostasisHumansMechanotransduction, CellularMiceMitochondriaModels, BiologicalNoisePlasma Membrane Calcium-Transporting ATPasesPlasma Membrane Calcium-Transporting ATPasesCalciumHearing lossMechanotransducer channelsMitochondriaPMCA2 calcium pumpStereociliary bundle

Identifiers

PMID30473131
PMCPMC6504959
OpenAlexW2901044552

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.